A kind of medicine and application thereof for preventing or treating fatty liver
A technology for fatty liver and simple fatty liver, applied in the field of medicine and biology, can solve problems such as strong side effects and difficulty in controlling the efficacy of drugs, and achieve the effect of repairing oxidative damage
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Embodiment 1
[0027] Example 1: Effect evaluation of oreoside A on prevention and treatment of non-alcoholic fatty liver
[0028]Take 18-22g Kunming mice and feed them with the high-fat and high-sugar foods shown in Table 1 continuously for 5 weeks, select the mice with the top 50% of body weight as model mice, and divide the model mice and normal mice into males and females Randomly divided into groups A-D, 4 groups in total, 10 mice in each group, half male and half male, respectively labeled, wherein group A is normal mice, and group B-D are model mice. Group A was fed with common feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group B was fed with high-fat feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group C was fed with high-fat feed and gavaged every day One time 200mg / kg of oreoside A (dissolved in 0.5% sodium carboxymethyl cellulose solution); D group feeding high-fat feed every day once 4mg / kg Rosiglitazone (dissolved in 0.5% c...
Embodiment 2
[0037] Example 2: Effect evaluation of different doses of oreoside A on prevention and treatment of non-alcoholic fatty liver
[0038] Take 18-22g Kunming mice and feed them with the high-fat and high-sugar foods shown in Table 1 continuously for 5 weeks, select the mice with the top 50% of body weight as model mice, and divide the model mice and normal mice into males and females Randomly grouped into groups A-E, 4 groups in total, 10 mice in each group, half male and half male, respectively labeled, wherein group A is normal mice, and group B-D are model mice. Group A was fed with common feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group B was fed with high-fat feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group C was fed with high-fat feed and gavaged every day The oreoside A of 50mg / kg once (dissolved in 0.5% sodium carboxymethyl cellulose solution); D group feeds the high-fat feed and gavages once a day the oreoside...
Embodiment 3
[0042] Example 3: Comparison of the effects of different flavonoid components on non-alcoholic fatty liver
[0043] Take 18-22g Kunming mice and feed them with the high-fat and high-sugar foods shown in Table 1 continuously for 5 weeks, select the mice with the top 50% of body weight as model mice, and divide the model mice and normal mice into males and females Randomly divided into groups A-H, 8 groups in total, 10 mice in each group, half male and half male, respectively labeled, of which group A is normal mice, B is model mice, and groups C-H use model mice to administer various flavonoid ingredients , flavonoids are all soluble in 0.5% sodium carboxymethyl cellulose solution. Group A was fed with common feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group B was fed with high-fat feed and gavaged 0.5% sodium carboxymethyl cellulose solution once a day; group C was fed with high-fat feed and gavaged every day Oreoside A at 800mg / kg once; Group D ...
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