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Gamma-polyglutamic acid/polylactic acid biocompatible nanofiber membrane and preparing method

A nanofiber membrane, polyglutamic acid technology, applied in fiber processing, textiles and papermaking, non-woven fabrics and other directions, can solve the problems of high intermolecular entanglement, inability to prepare stable nanofibers, etc., and achieve uniform spinning solution, The effect of stable performance and short preparation process

Active Publication Date: 2017-12-12
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing technology, γ-polyglutamic acid has a large number of hydrophilic groups and a high degree of entanglement between molecules, so it is impossible to prepare stable nanofibers by electrospinning technology.

Method used

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  • Gamma-polyglutamic acid/polylactic acid biocompatible nanofiber membrane and preparing method
  • Gamma-polyglutamic acid/polylactic acid biocompatible nanofiber membrane and preparing method
  • Gamma-polyglutamic acid/polylactic acid biocompatible nanofiber membrane and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) The compound solution of trifluoroacetic acid and chloroform is used as a solvent, and the volume ratio is 1:1, and 25 ml of solvent is prepared.

[0037] (2) Calculate and weigh the solute according to the concentration of 15% (wt), wherein the γ-polyglutamic acid and polylactic acid in the solute are in a mass ratio of 3:10;

[0038] (3) Add the weighed γ-polyglutamic acid into the above-mentioned compound solvent, and stir well to form a uniform solution A. Add the weighed polylactic acid powder into solution A, and stir thoroughly to prepare a uniform mixed solution B. The resulting mixed solution B is placed in an ultrasonic generator for defoaming to obtain a spinning stock solution;

[0039] (4) Using electrospinning, the spinning voltage is 25KV, the distance from the nozzle to the receiver is 20cm, and the feeding flow rate of the spinning stock solution is 0.2ml / h to prepare the γ-polyglutamic acid / polylactic acid biophase Holds the rice fiber membrane. ...

Embodiment 2

[0042] (1) The compound solution of trifluoroacetic acid and chloroform is used as a solvent, and the volume ratio is 1:1, and 25 ml of solvent is prepared.

[0043] (2) Calculate and weigh the solute according to the concentration of 16% (wt), wherein the γ-polyglutamic acid and polylactic acid in the solute are 2:10 by mass;

[0044] (3) Add the weighed γ-polyglutamic acid into the above-mentioned compound solvent, and stir well to form a uniform solution A. Add the weighed polylactic acid powder into solution A, and stir thoroughly to prepare a uniform mixed solution B. The resulting mixed solution B is placed in an ultrasonic generator for defoaming to obtain a spinning stock solution;

[0045] (4) Using electrospinning, the spinning voltage is 25KV, the distance from the nozzle to the receiver is 20cm, and the feeding flow rate of the spinning stock solution is 0.5ml / h to prepare the γ-polyglutamic acid / polylactic acid biophase Holds the rice fiber membrane.

[0046] (...

Embodiment 3

[0048] (1) The compound solution of trifluoroacetic acid and chloroform is used as a solvent, and the volume ratio is 1:1, and 25 ml of solvent is prepared.

[0049](2) Calculate and weigh the solute according to the concentration of 17% (wt), wherein the γ-polyglutamic acid and polylactic acid in the solute are 1:10 by mass;

[0050] (3) Add the weighed γ-polyglutamic acid into the above-mentioned compound solvent, and stir well to form a uniform solution A. Add the weighed polylactic acid powder into solution A, and stir thoroughly to prepare a uniform mixed solution B. The resulting mixed solution B is placed in an ultrasonic generator for defoaming to obtain a spinning stock solution;

[0051] (4) Using electrospinning, the spinning voltage is 22KV, the distance from the nozzle to the receiver is 18cm, and the feeding flow rate of the spinning stock solution is 0.5ml / h to prepare the γ-polyglutamic acid / polylactic acid biophase Holds the rice fiber membrane.

[0052] (5...

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Abstract

The invention relates to a gamma-polyglutamic acid / polylactic acid biocompatible nanofiber membrane and a preparing method. The preparing method includes the steps that gamma-polyglutamic acid and polylactic acid are dissolved according to the certain proportion (1:10 to 3:10) into a compounded solvent of trifluoroacetic acid and trichloromethane, wherein the volume ratio of the trifluoroacetic acid to the trichloromethane is 1:1, and an even solution with the certain concentration (15% to 18%, wt) is prepared; the nanofiber membrane is prepared with the electrospinning technology. The gamma-polyglutamic acid has the good water-retaining property and biocompatibility, and is nontoxic, harmless and edible; the polylactic acid is renewable, degradable and good in biocompatibility, and is an environment-friendly high polymer material. The composite nanofiber membrane prepared with the method has the advantages that the composite nanofiber membrane has the good biocompatibility, and is nontoxic and degradable, harmful substances are not generated, the good mechanical property is achieved, the hydrophobic property of the polylactic acid is improved, and products can be widely applied to the field of biological tissue culturing, medical ingredients, drug carriers and the like.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to a method for preparing a γ-polyglutamic acid nanocomposite fiber membrane with good biocompatibility, in particular to a method for preparing γ-polyglutamic acid / polylactic acid biophase through an electrospinning process Methods of containing rice fiber membranes. technical background [0002] Preparation of nanofiber membrane by electrospinning is a relatively simple and easy technology. The prepared nanofiber membrane material has a network structure, large specific surface area, high microporosity, and good connectivity. It is used in filtration and separation, tissue engineering, and medical applications. Materials, biological cell culture and other fields have good application prospects. [0003] γ-polyglutamic acid is a high-molecular anionic polypeptide polymer with a large number of amide bonds and free carboxyl groups in the molecule, mainly composed of D-glutamic acid and L-...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01D5/00
CPCD01D5/003D01D5/0061D01D5/0092D04H1/4382D04H1/728
Inventor 王海英孙戒迟波
Owner NANJING UNIV OF TECH