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Children's febrifuge ibuprofen capable of rapidly adjusting release rate produced by pressurized wrapping method

A rapid adjustment and release speed technology, applied in antipyretics, pharmaceutical formulations, drug combinations, etc., can solve problems such as no relevant research

Inactive Publication Date: 2017-12-22
锡山区东港全宝机械经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant research on the ropivacaine sustained-release drug delivery system using MBG as the carrier.

Method used

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  • Children's febrifuge ibuprofen capable of rapidly adjusting release rate produced by pressurized wrapping method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] Step 1: Preparation of SiO2 colloidal crystal template

[0017] Preparation of monodisperse SiO2 microspheres: using A method for the preparation of monodisperse SiO2 microsphere suspensions by an alkaline hydrolysis process of ethyl orthosilicate (TEOS). Weigh 251.2g of absolute ethanol, 118.25g of deionized water and 34g of NH3·H2O into a conical flask, mix well under magnetic stirring, add 27.7g of TEOS, and continue magnetic stirring for 3h to obtain a suspension of SiO2 particles.

[0018] Preparation of SiO2 colloidal crystal template: firstly, the suspension of SiO2 particles prepared above is removed by rotary evaporation to remove excess solvent, then placed in a flat-bottomed container, and centrifuged to remove excess solvent to form a large disordered SiO2 colloid crystal template, and then sintered at a high temperature of 1000 ° C to obtain a SiO2 colloidal crystal template.

[0019] Step 2: Preparation of Inverse Colloidal Carbon Template

[0020] SiO...

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Abstract

The present invention relates to children's antipyretic ibuprofen with rapid adjustment of release rate made by pressurized encapsulation method. PLA‑PEG wrapping layer, PEG and PLA‑PEG wrapping layers on the surface of mesoporous bioactive glass microspheres are uneven, and the surface of a single mesoporous bioactive glass microsphere is partially wrapped with PEG and PLA‑PEG layers, and some are partially unwrapped PEG and PLA‑PEG layers. It is characterized in that in the process of making the above-mentioned nano microspheres, the MBGs and the drug-loaded MBGs powder are evenly dispersed, spread on a flat surface with sufficient surface strength, and then another flat surface with sufficient hardness is pressed on the MBGs and drug-loaded-MBGs powder to pressurize, adjust the pressurization pressure, and then add chloroform solution of PEG and PLA-PEG dropwise around MBGs and drug-loaded-MBGs powder, just moisten, and keep ventilation at room temperature to Chloroform evaporates completely.

Description

technical field [0001] The invention relates to children's antipyretic ibuprofen which is produced by a pressurized wrapping method and whose release speed is quickly adjusted. Background technique [0002] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. [0003] Indicated for the treatment of mild to moderate migraine episodes, migraine prevention, chronic episodic hemigraine, exertion and menstrual headaches, rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis Inflammation and neuritis etc. [0004] Small-sized monodisperse drug-loaded mesoporous bioactive glass microspheres (MBGMs) / ethylene glycol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K9/51A61K47/02A61K47/10A61K47/34A61K31/192A61P29/00
CPCA61K9/5192A61K9/0002A61K9/5115A61K9/5146A61K31/192
Inventor 王全宝
Owner 锡山区东港全宝机械经营部