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Methods of Metrology Processing of Qualitative and Quantitative Measurement Data

A quantitative measurement and processing method technology, applied in the field of metrology processing of qualitative and quantitative measurement data, can solve the problem that quantitative measurement cannot be guaranteed, the accuracy and reliability of qualitative measurement results cannot be evaluated, and the biological measurement activities are affected. and other problems, to achieve the same mathematical meaning and ensure the effect of scientificity

Active Publication Date: 2021-03-30
NAT INST OF METROLOGY CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the GUM guidelines are able to address quantitative issues in biometrics, there are a considerable number of qualitative measurement issues in biometrics that cannot be covered by the GUM guidelines
For example, in biological measurement, "negative / positive" is widely used to judge, and the multi-value table indicating the strength of the reaction is "-", "±", "+", "++", "+++", "++ ++"; or text descriptions such as "negative", "weak negative", "weak positive", "positive"; or typing results expressed as "type I", "type II", "type III"; or sequence analysis As a result of "AGCTTA", etc., because these measurement results cannot be expressed numerically, the existing metrology principles and guidelines are not applicable to qualitative measurement results, so quantitative measurement in long-term biological There are no corresponding development guidelines for reference materials, and the accuracy and reliability of qualitative measurement results cannot be evaluated, which has affected biological measurement activities in the fields of in vitro diagnostics, biomedicine, food safety, and biosafety.

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  • Methods of Metrology Processing of Qualitative and Quantitative Measurement Data
  • Methods of Metrology Processing of Qualitative and Quantitative Measurement Data
  • Methods of Metrology Processing of Qualitative and Quantitative Measurement Data

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Embodiment 1——quantitative measurement

[0088] (1) For the fatty acid binding protein FABP, the sample was measured 10 times by isotope dilution mass spectrometry, and the results were 50, 51, 52, 50, 51, 53, 50, 52, 54, and 52 ng / μL. Expressed in a way, the measurement result set X can be expressed as:

[0089] X = {50, 51, 52, 53, 54}

[0090] Since the elements in the set are required to be different in mathematics, the value with the same measurement result is reflected as an element in the set. Clearly, a single measurement of x i are consistent with the following relationship:

[0091] x i ∈X

[0092] (2) Determination of the confidence range of FABP quantitative results. For the 10 quantitative measurement results of FABP: 50, 51, 52, 50, 51, 53, 50, 52, 54, 52ng / μL, the expanded uncertainty corresponding to the 95% confidence probability was evaluated according to the GUM guidelines. The average value of 10 measurement results is 51.5ng / μL, and the expan...

Embodiment 2

[0101] Example 2 - Qualitative Measurements

[0102] (1) Perform a qualitative test on a sample that may be mixed with genetically modified ingredients. According to the national testing standards for genetically modified ingredients, if the genetically modified ingredients are detected, report positive; if no genetically modified ingredients are detected, report negative. For this sample, the test is repeated 100 times, including 2 negative test results and 98 positive test results, which are expressed in a set way, then the measurement result set X can be expressed as:

[0103] X = {negative, positive}

[0104] Since the elements in the set are required to be different in mathematics, the value with the same measurement result is reflected as an element in the set. Clearly, a single measurement of x i are consistent with the following relationship:

[0105] x i ∈X

[0106] (2) Determination of the confidence range of the qualitative measurement results of the transgene....

Embodiment 3

[0113] Example 3 - Qualitative Measurements

[0114] (1) Use a urine analyzer to test the urine of a certain patient, and repeat the test 100 times for this sample, including 2 times when the test result of urine protein is "-", and 6 times when the test result is "±" , the detection result is "+" 92 times, which is represented by a set, then the measurement result set X can be expressed as:

[0115] X = {-, ±, +}

[0116] Since the elements in the set are required to be different in mathematics, the value with the same measurement result is reflected as an element in the set. Clearly, a single measurement of x i are consistent with the following relationship:

[0117] x i ∈X

[0118] (2) Determination of the confidence range of the qualitative measurement results of the urine test results. Qualitative measurement results for 100 urine samples: 2 times of "-", 6 times of "±", 92 times of "+", calculate the frequency of each element in the measurement result set, obviousl...

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Abstract

The invention relates to a metrology processing method for qualitative and quantitative measurement data. The metrology processing method comprises a measuring device, a control device and storage devices, and comprises the processing steps of measuring a measured object through the measuring device, collecting measured data, and storing the measured data in a first storage device; determining a confidence range for measured results, and saving the confidence range of the measurement results in a second storage device; determining the conformity of the measured results; extracting a single measured result xi from the first storage device in sequence, comparing with the confidence interval x of the measured results from the second storage device, and saving the determined results in a third storage device. The metrology processing method for the qualitative and quantitative measurement data achieves the expression of the qualitative measurement result by using a mathematical system, so that subsequent evaluation conclusions of qualitative measurements depend entirely on the operation of the mathematical system to describe, and the calculation and expression of the confidence range of qualitative and quantitative results under a specified probability are achieved.

Description

technical field [0001] The present invention relates to a data processing method, in particular to a metrology processing method for qualitative and quantitative measurement data. Background technique [0002] Metrology is an activity to achieve unit unity and accurate and reliable values. Research and establishment of high-accuracy measurement methods is one of the important contents of metrology research. Measurement is a process in which one or more values ​​can be reasonably assigned to a quantity obtained through experimentation. Measurement is divided into quantitative measurement and qualitative measurement. The results of quantitative measurement can usually be expressed in numerical values, while the results of qualitative measurement are usually not expressed in numerical values, or their values ​​are not continuous in the natural number set or real number set. [0003] With the development of life science and biotechnology, life science has experienced the develo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F17/18
CPCG16Z99/00
Inventor 武利庆罗一米薇盛灵慧金有训高运华王志栋杨彬王晶
Owner NAT INST OF METROLOGY CHINA