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Nano chitosan capable of quickly adjusting drug release rate

A nano-chitosan, rapid adjustment technology, applied in the direction of capsule delivery, microcapsules, nanocapsules, etc., can solve the problem of not really displaying the biological activity of chitosan

Inactive Publication Date: 2018-01-19
锡山区东港玉英家电经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the various chitosan products in my country are ordinary size chitosan, which fails to truly show the full picture of chitosan's biological activity and excellent medical properties, and the intervention of nanotechnology is the way to solve the above problems

Method used

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  • Nano chitosan capable of quickly adjusting drug release rate

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Experimental program
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Effect test

Embodiment Construction

[0015] 1.1 Materials

[0016] Chitosan (CS, molecular weight 5000Da, deacetylation degree 85%), Zhejiang Aoxing. DL-Lipoic Acid 99% (LA), Stearic Acid 98% (SA), 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride (EDC), N-Hydroxysuccinate Imide (NHS) and dithiothreitol (DTT) were purchased from Aladdin Reagents (China) Co., Ltd. Formic acid solution (concentration: 88%), formaldehyde solution (concentration: 40%), and absolute ethanol were all of analytical grade and purchased from Tianjin Reagent Wholesale Company.

[0017] 1.2 Preparation of grafted chitosan

[0018] Get 1g chitosan and be dissolved in 70mL deionized water, stearic acid (the mol ratio of the amino group of stearic acid and chitosan is 0.2:1) and 1.6g EDC and 0.95g NHS are dissolved in 35mL ethanol (EDC and The molar ratio of NHS to carboxyl group is 10:1), pre-reacted at room temperature for 0.5h, then added dropwise into chitosan aqueous solution, and reacted at 60°C for 2d. After the reaction, ...

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Abstract

The invention relates to nano chitosan capable of quickly adjusting a drug release rate. Nano chitosan serves as an inner core, a macromolecule polymer wrapping layer serves as an outer layer, the macromolecule polymer wrapping layer on the surface of the nano chitosan is uneven, the surface of some single nano chitosan is partially wrapped by the macromolecule polymer wrapping layer, and the surface of some single nano chitosan is not partially wrapped by the macromolecule polymer wrapping layer.

Description

technical field [0001] The present invention relates to nano-chitosan capable of rapidly adjusting drug release speed. Background technique [0002] Nano-chitosan is currently one of the most important nanotechnology products, widely used in biopharmaceuticals, disease diagnosis, purification treatment, environmental monitoring, paint coatings, cosmetics and many other fields. When nano-chitosan is used as a drug carrier, its ultra-small volume is easier to pass through the interstitial space, and directly transport the loaded drug to the target site through the capillary wall, gastric mucosa, intestinal mucosa and even the stratum corneum of the skin, slowly. Release, to achieve the purpose of sustained drug release and targeted drug delivery. This technology has improved the performance of drugs very well, solved many problems that currently affect the efficacy of drugs, and has attracted more and more attention in the sustained release of drugs. [0003] Nano-chitosan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/36A61K47/34A61K47/10
Inventor 王玉英
Owner 锡山区东港玉英家电经营部