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Children's febrifuge ibuprofen capable of quickly adjusting release rate

A release rate, fast adjustment technology, applied in antipyretics, pharmaceutical formulations, drug combinations, etc., can solve the problem of no related research on the ibuprofen sustained-release drug delivery system

Inactive Publication Date: 2018-01-19
锡山区东港晓鸣电子产品经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant research on the ibuprofen sustained-release drug delivery system with MBG as the carrier

Method used

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  • Children's febrifuge ibuprofen capable of quickly adjusting release rate

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Experimental program
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Embodiment Construction

[0015] Step 1: Preparation of SiO2 colloidal crystal template

[0016] Preparation of monodisperse SiO2 microspheres: Monodisperse SiO2 microsphere suspensions were prepared by an alkaline hydrolysis process of ethyl orthosilicate (TEOS) using Stöber's method. Weigh 251.2 g of absolute ethanol, 118.25 g of deionized water and 34 g of NH3·H2O into a conical flask, mix well under magnetic stirring, add 27.7 g of TEOS, and continue magnetic stirring for 3 h to obtain a suspension of SiO2 particles liquid.

[0017] Preparation of SiO2 colloidal crystal template: firstly, the suspension of SiO2 particles prepared above is removed by rotary evaporation to remove excess solvent, then placed in a flat-bottomed container, and centrifuged to remove excess solvent to form a large disordered SiO2 colloid crystal template, and then sintered at a high temperature of 1000 ° C to obtain a SiO2 colloidal crystal template.

[0018] Step 2: Preparation of Inverse Colloidal Carbon Template

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Abstract

The invention relates to a children's febrifuge ibuprofen nano-microsphere capable of quickly adjusting a release rate. Mesoporous biological active glass microspheres where ibuprofen is loaded serveas inner cores, macromolecule PEG and PLA-PEG wrapping layers serve as outer layers, the PEG and PLA-PEG wrapping layers on the surfaces of the mesoporous biological active glass microspheres are uneven, the surfaces of some single mesoporous biological active glass microspheres are partially wrapped by the PEG and PLA-PEG layers, and the surfaces of some single mesoporous biological active glassmicrospheres are not partially wrapped by the PEG and PLA-PEG layers.

Description

technical field [0001] The invention relates to ibuprofen, an antipyretic drug for children with rapidly adjusted release rate. Background technique [0002] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. [0003] Indicated for the treatment of mild to moderate migraine episodes, migraine prevention, chronic episodic hemigraine, exertion and menstrual headaches, rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis Inflammation and neuritis etc. [0004] Small-sized monodisperse drug-loaded mesoporous bioactive glass microspheres (MBGMs) / ethylene glycol lactic acid copolymer (PEG -PLA) nano-microsp...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/51A61K47/02A61K47/10A61K47/34A61K31/192A61P29/00
Inventor 王全宝
Owner 锡山区东港晓鸣电子产品经营部