Drug release rate rapid regulating nano insulin-chitosan produced by pressurizing coating method
A technology for rapid adjustment and release rate, which can be used in drug combination, drug delivery, pharmaceutical formulation, etc., and can solve the problem of failing to truly display insulin-chitosan
Inactive Publication Date: 2018-01-19
锡山区东港晓鸣电子产品经营部
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Problems solved by technology
Most of my country's various chitosan products are ordinary size insulin-chitosan, which fails to truly show the full picture of the biological activity and excellent medical properties of insulin-chitosan, and the intervention of nanotechnology is the way to solve the above problems
Method used
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[0017] 1.1 Material
[0018] Chitosan (CS, molecular weight is 5000Da, degree of deacetylation is 85%), Zhejiang Aoxing. DL-lipoic acid 99% (LA), stearic acid 98% (SA), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinate Both imide (NHS) and dithiothreitol (DTT) were purchased from Aladdin Reagent (China) Co., Ltd. Formic acid solution (concentration of 88%), formaldehyde solution (concentration of 40%), and absolute ethanol are all analytically pure and purchased from Tianjin Reagent Wholesale Company.
[0019] 1.2 Preparation of grafted chitosan
[0020] Dissolve 1g of chitosan in 70mL of deionized water, and dissolve stearic acid (the molar ratio of stearic acid to the amino groups of chitosan is 0.2:1), 1.6g EDC and 0.95g NHS in 35mL ethanol (EDC and The molar ratio of NHS and carboxyl groups is both 10:1), pre-reacted at room temperature for 0.5h, then added dropwise to the aqueous solution of chitosan, and reacted at 60℃ for 2d. After the r...
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Abstract
The invention relates to drug release rate rapid regulating nano insulin-chitosan produced by a pressurizing coating method. An inner core is nano insulin-chitosan; an outer layer is a high-molecularpolymer coating layer. The drug release rate rapid regulating nano insulin-chitosan is characterized in that the high-molecular polymer coating layer on the surface of the nano insulin-chitosan is uneven; part of the surface of one single piece of nano insulin-chitosan is coated with the high-molecular polymer coating layer and part of the surface is not coated with the high-molecular polymer coating layer. The drug release rate rapid regulating nano insulin-chitosan is characterized in that in the producing process of the nano insulin-chitosan, nano insulin-chitosan powder is uniformly dispersed and tiled on a flat, bright and clean plane with sufficient surface intensity, then another flat, bright and clean surface with sufficient hardness is pressed on the nano insulin-chitosan powder to carry out pressurizing, a pressurizing pressure is regulated well, then solution of high-molecular polymer is dropwise added around the nano insulin-chitosan powder to a wet state, and at a normal temperature, ventilation is kept until the solution is volatilized fully.
Description
Technical field [0001] The invention relates to a nano insulin-chitosan which is manufactured by a pressurization method and can quickly adjust the drug release rate. Background technique [0002] Insulin is a protein hormone secreted by the islet β cells in the pancreas stimulated by endogenous or exogenous substances such as glucose, lactose, ribose, arginine, glucagon, etc. Insulin is the only hormone in the body that lowers blood sugar, and at the same time promotes glycogen, fat, and protein synthesis. Exogenous insulin is mainly used to treat diabetes. [0003] Nano-chitosan is one of the most important nanotechnology products at present, and it is widely used in many fields such as biopharmaceuticals, disease diagnosis, purification treatment, environmental monitoring, paint coatings, cosmetics and so on. When nano chitosan is used as a drug carrier, its ultra-small volume can more easily pass through the interstitial space, and transport the loaded drug directly to the t...
Claims
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IPC IPC(8): A61K38/28A61K9/52A61K9/51A61K47/36A61K47/34A61K47/10A61P3/10
Inventor 顾炎
Owner 锡山区东港晓鸣电子产品经营部