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Gradient degradable biofilm scaffold material and preparation method thereof

A scaffold material, biofilm technology, applied in medical science, textiles and papermaking, prostheses, etc., can solve problems affecting the delivery of nutrients and metabolites, and difficulty in extracting or synthesizing bioactive factors, achieving superior performance, good biological Compatibility, effect of fast degradation rate

Active Publication Date: 2020-06-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the purification and cross-linking of natural polymers, as well as the difficulty in extracting or synthesizing bioactive factors, are important factors that limit its clinical application.
On the other hand, once one of the components in these bilayer structures degrades, it will form a dense barrier layer, which will greatly affect the delivery of nutrients and metabolites during tissue growth.

Method used

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  • Gradient degradable biofilm scaffold material and preparation method thereof
  • Gradient degradable biofilm scaffold material and preparation method thereof
  • Gradient degradable biofilm scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of polycaprolactone (PCL) electrospinning solution

[0042] Weigh 0.6 g of PCL particles, dissolve in 5 mL of trifluoroethanol, add 1.2 mg of calcium chloride, and stir for 1 h to obtain polycaprolactone spinning solution.

[0043] (2) Preparation of polyurethane (PU) electrospinning solution

[0044]Polyurethane synthesis: 20g PCL (molecular weight 2000) and 11.1g isophorone diisocyanate (IPDI) (molecular weight 222.28) were pre-polymerized under mechanical stirring, nitrogen atmosphere, 75°C for 4 h, and then about 0.1 mL stannous octoate was added Continue to stir for 1 h, then add 5 g of lysine ethyl ester hydrochloride to continue the reaction for 3 h, then add about 0.1 mL of stannous octoate for 2 h, then add 10 mL of deionized water and place the reaction system at 90°C for 2 h , the target product of degradable medical polyurethane material can be obtained by cooling down at room temperature.

[0045] Composite polyurethane (PUO) electrospinni...

Embodiment 2

[0051] (1) Preparation of polycaprolactone electrospinning solution

[0052] Weigh 0.7 g of PCL particles, dissolve in 5 mL of trifluoroethanol, add 2.1 mg of calcium nitrate, and stir for 1 h to obtain polycaprolactone spinning solution.

[0053] (2) Preparation of polyurethane electrospinning solution and polyurethane / n-HA mixed electrospinning solution

[0054] Polyurethane synthesis: 20g PCL (molecular weight 2000) and 11.1g isophorone diisocyanate (IPDI) (molecular weight 222.28) were prepolymerized for 6 h under mechanical stirring, nitrogen atmosphere, and a temperature of 75°C; then about 0.15 mL stannous octoate was added Continue to stir for 1 h, then add 5 g of ethyl lysine hydrochloride to continue the reaction for 3 h, then add about 0.15 mL of stannous octoate to react for 3 h, then add 10 mL of deionized water and place the reaction system at 90°C for aging After cooling for 10 h at room temperature, the target product of degradable polyurethane was obtained. ...

Embodiment 3

[0065] (1) Preparation of polycaprolactone electrospinning solution

[0066] Weigh 0.8 g of PCL particles, dissolve in 5 mL of dichloromethane, add 3.2 mg of calcium bromide, and stir for 1 h to obtain polycaprolactone spinning solution.

[0067] (2) Preparation of composite polyurethane electrospinning solution

[0068] Polyurethane synthesis: 40 g polycaprolactone diol (molecular weight 4000) and 9.05 g lysine diisocyanate (LDI) (molecular weight 226.23) were prepolymerized under mechanical stirring, nitrogen atmosphere, and 40 °C for 10 h, and then about Stir 0.15 mL of stannous chloride for 2 h, then add 8 g of PEG (molecular weight 400) and continue to react for 4 h, then add about 0.15 mL of stannous chloride for 3 h, then add 8 mL of deionized water and place the reaction system at 70 The target product of degradable polyurethane can be obtained by aging at ℃ for 10 h and cooling down at room temperature.

[0069] Composite polyurethane spinning solution: Dissolve 1.8...

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Abstract

Gradient degradable biofilm scaffold material and its preparation method. The biofilm scaffold material has a three-layer structure of inner, middle and outer layers combined with each other. The inner layer structure is an electrospun fiber membrane containing 2.5-10 wt% polyoxyethylene composite polyurethane in medical polyurethane material and mixed with 0-60 wt% nano-hydroxyapatite component in scaffold material; The middle layer structure covered on its surface is a mixed electrospun fiber membrane formed by interweaving electrospun fibers of polycaprolactone containing 2~5 wt‰ calcium salt components and composite polyurethane electrospun fibers; covered in the middle layer The outer structure of the structured surface is an electrospun fiber membrane of polycaprolactone containing 2-5 wt‰ calcium salt. The biofilm scaffold material can imitate the function of natural biofilm to promote tissue regeneration, and has wide applications in the field of biomedicine and industry.

Description

technical field [0001] The invention relates to a scaffold material used in the field of biomedicine, in particular to a biofilm scaffold material capable of gradient degradation, and a preparation method of the biofilm scaffold material. Background technique [0002] Tissue engineering scaffold is an important part of tissue repair at present, which can provide a corresponding place for cell adhesion growth, nutrient and gas exchange, waste excretion and growth metabolism. An ideal tissue engineering scaffold should not only mimic the fibrous structure of the natural extracellular matrix but also provide the tissue-specific biological functions. [0003] Electrospinning technology has gradually attracted the attention of researchers all over the world since it was realized by Formhals in 1934. The diameter of fibers obtained by electrospinning technology can vary from tens of nanometers to several microns. This kind of fiber material can have high specific surface area, p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/12A61L27/02A61L27/50A61L27/58D04H1/728
Inventor 左奕孙富华李玉宝杨博渊邹琴李吉东
Owner SICHUAN UNIV
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