Nano-chitosan prepared by pressurized coating method for rapidly adjusting drug release velocity
A nano-chitosan, rapid adjustment technology, applied in the direction of drug delivery, pharmaceutical formulation, capsule delivery, etc., can solve the problem of not really showing the biological activity of chitosan
Inactive Publication Date: 2018-01-30
锡山区东港玉英家电经营部
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Problems solved by technology
Most of the various chitosan products in my country are ordinary size chitosan, which fails to truly show the full picture of chitosan's biological activity and excellent medical properties, and the intervention of nanotechnology is the way to solve the above problems
Method used
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[0017] 1.1 Materials
[0018] Chitosan (CS, molecular weight 5000Da, deacetylation degree 85%), Zhejiang Aoxing. DL-Lipoic Acid 99% (LA), Stearic Acid 98% (SA), 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride (EDC), N-Hydroxysuccinate Imide (NHS) and dithiothreitol (DTT) were purchased from Aladdin Reagents (China) Co., Ltd. Formic acid solution (concentration: 88%), formaldehyde solution (concentration: 40%), and absolute ethanol were all of analytical grade and purchased from Tianjin Reagent Wholesale Company.
[0019] 1.2 Preparation of grafted chitosan
[0020] Get 1g chitosan and be dissolved in 70mL deionized water, stearic acid (the mol ratio of the amino group of stearic acid and chitosan is 0.2:1) and 1.6g EDC and 0.95g NHS are dissolved in 35mL ethanol (EDC and The molar ratio of NHS to carboxyl group is 10:1), pre-reacted at room temperature for 0.5h, then added dropwise into chitosan aqueous solution, and reacted at 60°C for 2d. After the reaction, ...
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Abstract
The invention relates to nano-chitosan prepared by a pressurized coating method for rapidly adjusting drug release velocity, an inner core is the nano-chitosan and an outer layer is a high-molecular polymer coating layer, and the nano-chitosan is characterized in that the high-molecular polymer coating layer on the surface of the nano-chitosan is uneven, and the surface of a single nano-chitosan is partially coated with the high-molecular polymer coating layer while part of the surface of the single nano-chitosan are not coated with the high-molecular polymer coating layer. The method is characterized by comprising the steps that in a process of preparing the nano-chitosan, nano-chitosan powder is uniformly dispersed and is tiled on a flat and smooth surface with sufficient surface strength, and another flat and smooth surface with sufficient rigidity is pressed on the nano-chitosan powder for pressurizing, pressure is adjusted, and then a high-molecular polymer solution is dropwise dropped around the nano-chitosan powder for humidifying, and ventilation is maintained at room temperature until the solution is completely evaporated.
Description
technical field [0001] The invention relates to the nano-chitosan prepared by a pressurized encapsulation method to rapidly adjust the drug release rate. Background technique [0002] Nano-chitosan is currently one of the most important nanotechnology products, widely used in biopharmaceuticals, disease diagnosis, purification treatment, environmental monitoring, paint coatings, cosmetics and many other fields. When nano-chitosan is used as a drug carrier, its ultra-small volume is easier to pass through the interstitial space, and directly transport the loaded drug to the target site through the capillary wall, gastric mucosa, intestinal mucosa and even the stratum corneum of the skin, slowly. Release, to achieve the purpose of sustained drug release and targeted drug delivery. This technology has improved the performance of drugs very well, solved many problems that currently affect the efficacy of drugs, and has attracted more and more attention in the sustained releas...
Claims
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Login to View More IPC IPC(8): A61K9/52A61K9/51A61K47/36A61K47/34A61K47/10
Inventor 王全宝
Owner 锡山区东港玉英家电经营部