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Application of MIR135HG in cardiovascular system regulation

A cardiovascular and heart disease technology, applied in the direction of cardiovascular system diseases, medical preparations containing active ingredients, microbial measurement/testing, etc., can solve problems such as unclear problems

Inactive Publication Date: 2018-02-02
GUANGDONG CARDIOVASCULAR INSITITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above theories are the main pathogenic theories at present, there are still many problems that have not been clarified and need further research

Method used

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  • Application of MIR135HG in cardiovascular system regulation
  • Application of MIR135HG in cardiovascular system regulation
  • Application of MIR135HG in cardiovascular system regulation

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Experimental program
Comparison scheme
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Embodiment Construction

[0017] Prognosis of Cardiovascular Development

[0018] Identification and function prediction of long non-coding RNA genes

[0019] The inventor downloaded and compiled 60,000 pieces of GEO's Affy U133Plus 2 human chip expression data, and found gene groups related to human cardiovascular development through mining and co-expression analysis. Through co-expression analysis, find out the gene group related to the relevant expression level: the inventor through the co-expression analysis of the GEO Affy chip expression profile, is the gene that has a positive correlation between the expression level and the gene MIR135HG, for example, through the correlation function, Find out the top 32 genes with positive regulatory correlation (corr>0.40), (Table 1). The gene names in Table 1 are standard human gene names from GeneCards http: / / www.genecards.org / .

[0020] Table 1: Co-expressed genes of MIR135HG

[0021] serial number

Affy probe

Gene

gene name

p-va...

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Abstract

The invention discloses MIR135HG and its application in regulating the cardiovascular system. The inventors newly discovered that the expression level of the long non-coding gene MIR135HG in cardiac specimens is very highly correlated with MYH11, and it regulates the same group of cardiovascular development-related genes and protein groups of the cardiovascular system. By detecting the expression of MIR135HG, it is expected to screen cardiovascular system diseases and guide the development and treatment of cardiovascular system drugs. It is expected to treat or improve cardiovascular system diseases by regulating the expression of MIR135HG.

Description

technical field [0001] The present invention relates to the field of genes, in particular to the field of long non-coding RNA (lncRNA). Background technique [0002] Long non-coding RNAs (long non-coding RNAs, lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides and almost no protein-coding function. lncRNA affects physiological processes such as cell growth, development, proliferation, differentiation, metabolism, and apoptosis at multiple levels (epigenetic regulation, transcriptional regulation, and post-transcriptional regulation, etc.). In recent years, lncRNA, as a new transcript, has set off a widespread research boom in the field of genome research. Genomic studies have shown that more than 98% of mammalian genes are transcribed into non-coding RNA (non-coding RNA, ncRNA), and less than 2% are transcribed into proteins. ncRNAs can be divided into small non-coding RNAs and long non-coding RNAs according to their length. Studies have sh...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883A61K45/00A61K49/00A61P9/00A61P9/12A61P9/10A61P9/04A61P9/06
CPCC12Q1/6883A61K45/00A61K49/0008C12Q2600/118C12Q2600/158
Inventor 庄建李晓红陈寄梅刘小清周成斌
Owner GUANGDONG CARDIOVASCULAR INSITITUTE