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A kind of synthetic method of beta-carotene

A technology of carotene and a synthesis method, applied in the field of synthesis of beta-carotene, can solve the problems of polluting the environment, unfavorable mass production, inconvenience in purifying products, etc., and achieves the effects of simple reaction operation, few side reactions and high purity

Active Publication Date: 2019-09-24
XIAMEN KINGDOMWAY VI TAMIN INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In the second process, the invention patent CN101081829B and the invention patent application CN101041631A disclose the use of an organic phosphine salt of vitamin A alcohol or its derivatives in the presence of an oxidizing agent to obtain β-carotene by oxidative coupling reaction, and the oxidizing agent used is hypochlorous salt, chlorate, hydrogen peroxide, percarbonic acid, oxygen or air, the oxidative coupling process uses a large number of coupling oxidants, these oxidants not only bring inconvenience to the subsequent purification products, but also pollute the environment, which is not conducive to mass production

Method used

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  • A kind of synthetic method of beta-carotene
  • A kind of synthetic method of beta-carotene
  • A kind of synthetic method of beta-carotene

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Embodiment 1

[0040] A square electrolyzer with a capacity of 1L, which is equipped with inlet and outlet ports, cooling coils, thermometers, dropping funnels, and exhaust gas pipelines. The electrode material is a platinum electrode, and the two electrodes are respectively installed on two opposite sides of the electrolytic cell.

[0041] Mix 500ml of potassium carbonate aqueous solution with a concentration of 0.5 moles per liter and 250ml of vitamin A triphenylphosphine bisulfate solution with a concentration of 0.1 moles per liter, add to the electrolytic cell, and use 100A / dm 2 The current electrolysis for 4 hours. The reaction temperature was maintained at 15°C. After the reaction, filter out the precipitate, wash the precipitate with warm water at 65°C, filter, then heat with methanol at 65°C for 6 hours to isomerize, remove triphenylphosphine oxide, filter, and dry to obtain deep red β-carotene crystallization. The detected content of β-carotene was 99.2%, and the total yield was...

Embodiment 2

[0043] Electrolyzer is with embodiment 1.

[0044] Pour 500ml of KOH aqueous solution with a concentration of 0.5 moles per liter and 250ml of vitamin A triphenylphosphine hydrobromide aqueous solution with a concentration of 0.1 moles per liter into the electrolytic cell, and use 60A / dm 2The current electrolysis for 8 hours. The reaction temperature was maintained at 15°C. After the reaction, the precipitate was filtered out, washed with warm water at 65°C, filtered, then heated with methanol at 65°C for 6 hours for isomerization, and triphenylphosphine oxide was removed, filtered, and dried to obtain deep red β-carotene crystals. The detected content of β-carotene was 98.1%, and the total yield was 50.3%.

Embodiment 3

[0046] Electrolyzer is with embodiment 1.

[0047] Pour 500ml of sodium carbonate aqueous solution with a concentration of 0.5 moles per liter and 250ml of vitamin A tricresylphosphine hydrochloride aqueous solution with a concentration of 0.1 moles per liter into the electrolytic cell, and use 300A / dm 2 The current electrolysis for 8 hours. The reaction temperature was maintained at 15°C. After the reaction, the precipitate was filtered out, washed with warm water at 65°C, filtered, then heated with ethanol at 78°C for 4 hours for isomerization, and triphenylphosphine oxide was removed, filtered, and dried to obtain deep red β-carotene crystals. The detected content of β-carotene was 99.1%, and the total yield was 72.6%.

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Abstract

The present invention relates to a synthesis method of β-carotene, specifically dissolving the organic phosphine salt I of vitamin A alcohol or its derivatives in a solvent, and under the catalysis of a basic compound, an oxidative coupling reaction occurs under the action of an electric current , to get β-carotene. The present invention uses electro-oxidation instead of chemical oxidation reagents to prepare β-carotene by oxidatively coupling organic phosphine salts of vitamin A alcohol or its derivatives, the reaction operation is simple, and side reactions are few, green and environmentally friendly, and the product separation is fast and simple, and the purity is high .

Description

technical field [0001] The invention relates to a method for synthesizing organic matter, in particular to a method for synthesizing β-carotene. Background technique [0002] β-carotene is a source of vitamin A, which can be used in medicine, food, cosmetics, feed additives, and dyes, and has a good market prospect. [0003] There are many synthesis methods of β-carotene disclosed at present. The techniques for synthesizing β-carotene with vitamin A and its derivatives as starting materials include: [0004] 1. An organic phosphine salt obtained by reacting vitamin A alcohol or its derivatives with a triarylphosphine, which is further condensed with vitamin A aldehyde by Wittig reaction to obtain β-carotene. In this process, the Wittig reaction requires anhydrous and oxygen-free conditions, and the conditions are harsh, and the chemical properties of vitamin A aldehyde are unstable, so it is not easy for industrial preparation. The reaction formula is as follows: [0005...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25B3/10C25B3/29
CPCC25B3/29
Inventor 黄聿魏何剑洋叶艳秋谢德刚
Owner XIAMEN KINGDOMWAY VI TAMIN INC
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