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Child antipyretic ibuprofen made by adopting pressurization wrapping process and capable of rapidly adjusting release rate

A release speed, rapid adjustment technology, applied in the direction of antipyretics, drug combinations, inorganic non-active ingredients, etc., can solve problems such as no relevant research

Inactive Publication Date: 2018-02-06
锡山区东港晓鸣电子产品经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant research on the ropivacaine sustained-release drug delivery system using MBG as the carrier.

Method used

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  • Child antipyretic ibuprofen made by adopting pressurization wrapping process and capable of rapidly adjusting release rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] Step 1: Preparation of SiO2 colloidal crystal template

[0018] Preparation of monodisperse SiO2 microspheres: Monodisperse SiO2 microsphere suspensions were prepared by an alkaline hydrolysis process of ethyl orthosilicate (TEOS) using Stöber's method. Weigh 251.2 g of absolute ethanol, 118.25 g of deionized water and 34 g of NH3·H2O into a conical flask, mix well under magnetic stirring, add 27.7 g of TEOS, and continue magnetic stirring for 3 h to obtain a suspension of SiO2 particles liquid.

[0019] Preparation of SiO2 colloidal crystal template: firstly, the suspension of SiO2 particles prepared above is removed by rotary evaporation to remove excess solvent, then placed in a flat-bottomed container, and centrifuged to remove excess solvent to form a large disordered SiO2 colloid crystal template, and then sintered at a high temperature of 1000 ° C to obtain a SiO2 colloidal crystal template.

[0020] Step 2: Preparation of Inverse Colloidal Carbon Template

[...

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PUM

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Abstract

The present invention relates to the production process of children's antipyretic ibuprofen with speed-adjusted release rate. Spread the powder evenly on a flat surface with sufficient surface strength, then press another smooth surface with sufficient hardness on the above powder to pressurize, adjust the pressing pressure, and then drop by drop around the above powder Add the high molecular polymer solution dropwise, just moisten it, and keep ventilated at room temperature until the volatilization is complete.

Description

technical field [0001] The invention relates to children's antipyretic ibuprofen which is produced by a pressurized wrapping method and whose release speed is quickly adjusted. Background technique [0002] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. [0003] Indicated for the treatment of mild to moderate migraine episodes, migraine prevention, chronic episodic hemigraine, exertion and menstrual headaches, rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis Inflammation and neuritis etc. [0004] Small-sized monodisperse drug-loaded mesoporous bioactive glass microspheres (MBGMs) / ethylene glyc...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K47/02A61K47/10A61K47/34A61P29/00A61P25/06A61P19/02A61P19/08A61P25/00
CPCA61K31/192A61K47/02A61K47/10A61K47/34
Inventor 王全宝
Owner 锡山区东港晓鸣电子产品经营部