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Hardystonite/calcium silicate composite bioceramic material and preparation method thereof

A technology of composite bioceramics and zeolite, which is applied in the field of zeolite/calcium silicate composite bioceramic materials and its preparation, can solve the problems of unfavorable cell production and survival, decreased mechanical strength, and high degradation rate, so as to achieve easy popularization and application, The effect of simple operation and simple preparation process

Active Publication Date: 2018-03-02
LIAOCHENG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the high degradation rate of calcium silicate ceramics can easily reduce its mechanical strength; on the other hand, the dissolution effect of the material can easily cause a significant increase in the pH value of the liquid medium around the material, and a high pH value environment is not conducive to the production and survival of cells

Method used

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  • Hardystonite/calcium silicate composite bioceramic material and preparation method thereof
  • Hardystonite/calcium silicate composite bioceramic material and preparation method thereof
  • Hardystonite/calcium silicate composite bioceramic material and preparation method thereof

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preparation example Construction

[0025] A preparation method of zeolite / calcium silicate composite bioceramic material, comprising the following steps:

[0026] In step 1), calcium silicate and sauconite are prepared respectively, and powders are obtained after ball milling and sieving.

[0027] In step 2), the powders prepared in step 1) are uniformly mixed, cold isostatically pressed and then put into a muffle furnace for sintering to obtain zeolite / calcium silicate composite bioceramics.

[0028] The preparation method of calcium silicate powder in step 1) is as follows: configure equal concentration Ca(NO 3 ) 2 4H 2 O and NaSiO 3 9H 2 O two solutions, the NaSiO 3 9H 2 The O solution was slowly added dropwise to the Ca(NO 3 ) 2 4H 2 In the O solution, use a stirrer to continuously stir until the equimolar reaction of the two solutions is complete. The white flocculent precipitate formed by the reaction was repeatedly washed with deionized water and absolute ethanol, then dried in a drying oven, c...

Embodiment 1

[0032] (1) Weigh 47.228g Ca(NO 3 ) 2 4H 2 O and 56.844g NaSiO 3 9H 2 O, were dissolved in 1L deionized water to configure a 0.2mol / L solution, and the configured NaSiO 3 9H 2 The O solution was slowly added dropwise to the Ca(NO 3 ) 2 4H 2 O solution, and use a stirrer to continue stirring until the two solutions have reacted. The white flocculent reaction precipitate was repeatedly washed and filtered with deionized water and absolute ethanol, dried in a drying oven, calcined in a muffle furnace at 700°C for 2 hours, ground and sieved to obtain 38-76um calcium silicate powder .

[0033] (2) Weigh 178.32ml of ethyl orthosilicate, 188.92g of calcium nitrate tetrahydrate, and 118.80g of zinc nitrate hexahydrate as silicon source, calcium source and zinc source. During preparation, add 144ml of water, tetraethyl orthosilicate, and 20ml of 2mol / L nitric acid solution in sequence, stir magnetically for 2 hours, then add the corresponding calcium nitrate tetrahydrate and z...

Embodiment 2

[0036] Steps 1 and 2 in this embodiment are prepared according to steps (1) and (2) in Embodiment 1 to prepare calcium silicate powder and saunate feldspar powder.

[0037] (3) Weigh 54g of calcium silicate powder and 6g of zinc feldspar powder and mix them fully in a planetary ball mill, use a press to prepare a green body by cold isostatic pressing, put the green body into a muffle furnace, and heat the green body at 3°C / min Heat to 1000°C at a heating rate of 1,000°C and keep the temperature for 1 hour. The sample is cooled to room temperature to obtain the composite bioceramic material.

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Abstract

The invention discloses a hardystonite / calcium silicate composite bioceramic material and a preparation method thereof. The composite bioceramic material comprises the components of Ca2ZnSi2O7 and CaSiO3 and is a controllable-degradation hardystonite / calcium silicate composite bioceramic material. The method comprises the following steps of: respectively preparing uniform calcium silicate and hardystonite powder by using a precipitation method and a sol-gel method; uniformly mixing the powder, carrying out cold isostatic pressing forming, and carrying out sintering by using a muffle furnace toobtain the hardystonite / calcium silicate composite bioceramic material. By adjusting the content of the hardystonite in the mixed powder and the sintering temperature and time, a controllable and adjustable degradation rate of the composite ceramic material is realized on the premise of ensuring the biological activity of the composite material, and the requirements of bone tissue growth speed ofpatients at different age stages and different repair parts are met. The hardystonite / calcium silicate composite bioceramic material provided by the invention has the advantages of simple and rapid preparation process, simple and controllable operation and easy popularization and application.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a schertite / calcium silicate composite bioceramic material and a preparation method thereof. Background technique [0002] Bioceramic materials have specific biological or physiological functions, and are widely used in orthopedics, plastic surgery, dentistry, oral surgery and other fields as biological hard tissue replacement materials. With the continuous development of life science and material science, the requirements for biomaterials are also increasing. They should not only have good biological activity and biocompatibility, but also have suitable degradability. During the degradation process, tissue regeneration can be induced. Promote the body's own repair. At the same time, it is worth noting that patients of different ages and different repair sites have different bone tissue growth rates, and have different requirements for the activity and degradation speed of implant ma...

Claims

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Application Information

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IPC IPC(8): C04B35/22C04B35/626
CPCC04B35/22C04B35/626C04B2235/443C04B2235/483C04B2235/5436
Inventor 马杰王长征黄宝旭赵性川
Owner LIAOCHENG UNIV