White light-emitting up-conversion nanoparticle and test paper strip based on white light-emitting up-converting nanoparticle and capable of simultaneously detecting multi-component tumor markers

A technology of tumor markers and nanoparticles, which is applied in the field of up-conversion test paper detection of multi-component tumor markers, can solve the problems of affecting detection efficiency and complicated manufacturing process, and achieve good safety, high accuracy and specificity, The effect of removing background distractions
CN107748147AActive Publication Date: 2018-03-02HEFEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
HEFEI UNIV OF TECH
Publication Date
2018-03-02

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Abstract

The invention discloses a white light-emitting up-conversion nanoparticle and a test paper strip based on the white light-emitting up-converting nanoparticle and capable of simultaneously detecting multi-component tumor markers. According to the present invention, the nanoparticle has a three-layer core-shell structure, and emits white light under the excitation of near infrared light; and after the antibodies of multi-component tumor markers to be detected are labeled with the nanoparticle, the obtained conjugates are immobilized on the labeling complex binding zone of the test paper strip, such that the multiple tumor markers can be simultaneously detected; and with the nanoparticle and the test paper strip, the sensitive detection on the multiple tumor markers by the single up-conversion nanoparticle is achieved, and the advantages of simple operation, good specificity, high qualitative and quantitative real-time detection and high sensitivity are provided.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical diagnosis, and in particular relates to an up-conversion test paper detection method for multi-component tumor markers. Background technique

[0002] Malignant tumors are often referred to as cancer. The expression of some genes in the body is out of control. The malignant proliferation of cells destroys the normal life activities of the body. Its growth speed is fast, which will cause weight loss, fever, and serious organ damage. The final crisis life. At present, cancer has become the number one killer threatening people's lives. Therefore, early detection of cancer and timely clinical monitoring have become a major issue in modern biomedicine. With the maturity of nanotechnology, the combination platform of nanotechnology and cancer markers for the detection of tumor markers has become a hot spot. Colloidal gold test strips are the earliest widely used immunochromatographic test strips. I...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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