Synthesis method for ester compound
A technology of ether compound and synthesis method, which is applied in the field of synthesis of organic compounds and achieves the effects of high yield, strong substrate universality and mild reaction conditions
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Embodiment 1
[0025]
[0026] Add 0.3mmol of α-vinyl o-phenylbenzyl alcohol, 0.18mmol of potassium persulfate, and 0.6mmol of sodium trifluoromethanesulfonate into a 15mL pressure-resistant tube, and then add 2.4mL of 1,4-dioxane as a solvent. Next, magnetically stir at 45° C. for 12 h. Then, the reaction solution was cooled to room temperature, the filter residue was removed by filtration, and the filter residue was washed with dichloromethane, the filtrate was combined, two spoonfuls of column chromatography silica gel (100-200 mesh) were added to the filtrate, and the solvent was removed by distillation under reduced pressure. The residue was separated by column chromatography (petroleum ether: ethyl acetate volume ratio = 15:1 as the eluent), and the eluate containing the target product was collected, and the solvent was evaporated to obtain the pure product. The substance is a light yellow liquid, the chemical name is bis-(2-phenylphenyl)allyl ether, the amount of the purified subst...
Embodiment 2
[0029]
[0030] Add 0.3mmol of α-vinyl o-phenylbenzyl alcohol, 0.09mmol of potassium persulfate, and 0.9mmol of sodium trifluoromethanesulfonate into a 15mL pressure-resistant tube, and then add 1.5mL of 1,4-dioxane as a solvent. Then, magnetic stirring was performed at 25 °C for 8 h. Then, the reaction solution was cooled to room temperature, the filter residue was removed by filtration, and the filter residue was washed with dichloromethane, the filtrate was combined, two spoonfuls of column chromatography silica gel (100-200 mesh) were added to the filtrate, and the solvent was removed by distillation under reduced pressure. The residue was separated by column chromatography (petroleum ether: ethyl acetate volume ratio = 15:1 as the eluent), and the eluate containing the target product was collected, and the solvent was evaporated to obtain the pure product. The substance is a light yellow liquid, the chemical name is bis-(2-phenylphenyl)allyl ether, the amount of the pu...
Embodiment 3
[0033]
[0034] Add 0.3mmol of α-vinyl o-phenylbenzyl alcohol, 0.3mmol of potassium persulfate, and 0.9mmol of copper trifluoromethanesulfonate into a 15mL pressure-resistant tube, and then add 3.0mL of 1,4-dioxane as a solvent. Then, magnetically stirred at 80° C. for 24 h. Then, the reaction solution was cooled to room temperature, the filter residue was removed by filtration, and the filter residue was washed with dichloromethane, the filtrate was combined, two spoonfuls of column chromatography silica gel (100-200 mesh) were added to the filtrate, and the solvent was removed by distillation under reduced pressure. The residue was separated by column chromatography (petroleum ether: ethyl acetate volume ratio = 15:1 as the eluent), and the eluate containing the target product was collected, and the solvent was evaporated to obtain the pure product. The substance is a light yellow liquid, the chemical name is bis-(2-phenylphenyl)allyl ether, the amount of the purified sub...
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