Unlock instant, AI-driven research and patent intelligence for your innovation.

Determining method of sulfachloropyrazine sodium residue in florfenicol solution

A technology of sulfachloropyrazine sodium and florfenicol is applied in the directions of measuring devices, instruments, scientific instruments and the like to achieve the effects of short detection period, high sensitivity and simple detection method

Inactive Publication Date: 2018-03-09
RINGPU TIANJIN BIOLOGICAL PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In view of the fact that the current domestic detection method has not been used to determine the residues of sulfachlorpyrazine sodium in Florfenicol, it is very important to study a high performance liquid chromatography method to determine the residues of sulfachlorpyrazine sodium in Florfenicol. necessary

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Determining method of sulfachloropyrazine sodium residue in florfenicol solution
  • Determining method of sulfachloropyrazine sodium residue in florfenicol solution
  • Determining method of sulfachloropyrazine sodium residue in florfenicol solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] Preparation of Florfenicol Solution:

[0036] Sample 1, the Florfenicol solution prepared by the method of Example 1 disclosed in CN105796488A;

[0037] Sample 2, the Florfenicol solution prepared by the method of Example 2 disclosed in CN105125483A.

[0038] The assay method of residual amount of sulfachlorpyrazine sodium in Florfenicol solution of the present invention comprises the following steps:

[0039] Preparation of standard stock solution: Accurately weigh the sulfachlorpyrazine sodium standard substance, dissolve it in acetonitrile, prepare a standard stock solution with the same concentration as 1 mg / L, and store it at -20°C (the validity period is 1 month); Before use, accurately measure the standard stock solution, dilute it with the mobile phase into a series of standard working solutions of 10ng / ml, 20ng / ml, 50ng / ml, 100ng / ml, 200ng / ml and 500ng / ml, and keep away from it at 4°C. Store in light and use on the same day; preparation of mobile phase: aceto...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
correlation coefficientaaaaaaaaaa
recovery rateaaaaaaaaaa
Login to View More

Abstract

The invention relates to a determining method of sulfachloropyrazine sodium medicine residue in a florfenicol solution, and is a high performance liquid chromatography method. The method comprises thefollowing steps of sample preparation, sample pretreatment (taking uniformly mixed samples to be tested to be mixed with a flowing phase according to a ratio of 1:1; performing filtering; using obtained materials as test specimens to be tested; filtering a solution by a filtering membrane; performing HPLC analysis, standard solution preparation, and high performance liquid chromatography determination. The determining method provided by the invention has the advantages that the operation is convenient, simple and fast; the recovery rate is high; the repetitiveness is high.

Description

technical field [0001] The invention relates to a method for determining the residual amount of sulfachlorpyrazine sodium in florfenicol solution. Background technique [0002] Sulfonamide drugs are a class of broad-spectrum antibacterial drugs with a sulfanilamide structure. They are stable in nature, definite in curative effect, easy to use and low in price. Sexual rhinitis, etc., also has a good effect on poultry various coccidiosis, carinii leukoprotozoon disease, etc. The action characteristics of sulfachlorpyrazine sodium on poultry coccidiosis are similar to those of sulfaquinoxaline, and it has stronger antibacterial effect, and can even treat fowl cholera and fowl typhoid, so it is most suitable for the treatment of coccidiosis outbreaks, and is not Affect host immunity to coccidia. Although the toxicity of sulfachlorpyrazine sodium is lower than that of sulfaquinoxaline, symptoms of sulfa drug poisoning will still occur after long-term application, and improper o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 刘拓付春香李旭东刘爱玲夏雪林
Owner RINGPU TIANJIN BIOLOGICAL PHARMA