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Method for preparing hollow microcapsules from gallate extract and its application

A technology of gallons and extracts, applied in the field of medicine

Active Publication Date: 2021-03-16
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research on the preparation of hollow microcapsules by LBL technology and its treatment of inflammatory bowel disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Step 1. Add water to decoct the gallic medicinal material to obtain the gallic water extract. Step 2, 1 part of 1M Na 2 CO 3 Add to the equivalent amount of 1M CaCl containing 0.1 part of PSS and other polymers 2 , stirred vigorously for 1 min, filtered the solution, and dried to obtain CaCO doped with PSS 3 template. Step 3, take 0.1 part of CaCO obtained in step 2 3 Evenly suspend in 0.2 parts of gall seed extract, then insert a rusty iron rod, and react for 60 minutes. Then add 4 parts of buffer solution to adjust the pH to 8.0. After reacting for 20 minutes, the suspension was centrifuged and washed 3 times with water. After dissolving the template with EDTA, it was centrifuged and washed with water to obtain hollow microcapsules of gallate extract. Hollow microcapsules can be targeted and enriched in inflammatory bowel disease lesions, effectively antibacterial, anti-inflammatory, and anti-inflammatory bowel disease.

Embodiment 2

[0016] Example 2: Step 1. Add water to decoct the gallic medicinal material, concentrate under reduced pressure, extract the aqueous layer with ethyl acetate to obtain the gallic extract. Step 2, 1 part of 1M Na 2 CO 3 Add to the equivalent amount of 1M CaCl containing 0.1 part of PSS and other polymers 2 , stirred vigorously for 1 min, filtered the solution, and dried to obtain CaCO doped with PSS 3 Microcapsules. Step 3, take 0.1 part of CaCO obtained in step 2 3 Evenly suspend in 0.2 parts of gall seed extract, then insert a rusty iron rod, and react for 60 minutes. Then add 4 parts of buffer solution to adjust the pH to 8.0. After reacting for 20 minutes, the suspension was centrifuged and washed 3 times with water. After dissolving the template with EDTA, it was centrifuged and washed with water to obtain hollow microcapsules of gallate extract. Hollow microcapsules can be targeted and enriched in inflammatory bowel disease lesions, effectively antibacterial, anti-in...

Embodiment 3

[0017] Example 3: Step 1. Add water to decoct the gallic medicinal material, concentrate under reduced pressure, extract the water layer with ethyl acetate to obtain the gallic extract. Step 2, 1 part of 1M Na 2 CO 3 Add to the equivalent amount of 1M CaCl containing 0.1 part of PSS and other polymers 2 , stirred vigorously for 1 min, filtered the solution, and dried to obtain CaCO doped with PSS 3 template. Step 3, take 0.1 part of CaCO obtained in step 2 3 Evenly suspend in 0.2 parts of gall seed extract, then insert a rusty iron rod, and react for 60 minutes. Then add 4 parts of buffer solution to adjust the pH to 8.0. After reacting for 20 minutes, the suspension was centrifuged and washed 3 times with water. After dissolving the template with EDTA, it was centrifuged and washed with water to obtain hollow microcapsules of gallate extract. Hollow microcapsules can be targeted and enriched in inflammatory bowel disease lesions, effectively antibacterial, anti-inflammat...

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PUM

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Abstract

The invention relates to a method for preparing a hollow micro-capsule by nutgall extracts and an application of the nutgall extracts. The method is characterized in that water is added into nutgalls,and the nutgalls are decocted, decompressed and concentrated to obtain the nutgall extracts. Na2CO3 is added into equivalent CaCl2 solution containing high-molecular compounds such as PSS (sodium polystyrene sulfonate) or PEI (polyetherimide) and PS (polystyrene), and the solution is subjected to suction filtration and dried to obtain a PSS doped CaCO3 template. CaCO3 template solution is added into the nutgall extracts and iron ions and self-assembled to obtain the hollow micro-capsule. The nutgall extracts are prepared into the hollow micro-capsule, and the application of the nutgall extracts is widened. Besides, the surface of the hollow micro-capsule contains a large quantity of phenolic hydroxy, and a good foundation is provided for functional modification of carriers by chemical means. The hollow micro-capsule prepared from the nutgall extracts can be enriched at a focus of an inflammatory bowel disease in a targeted manner, bacteria are effectively resisted, inflammation is effectively diminished, and injury caused by the inflammatory bowel disease is resisted.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hollow microcapsule of gallate extract and a preparation method thereof, the use of the hollow microcapsule to selectively adsorb on the surface of inflammation and its use in treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory disease of the intestinal tract, mainly including ulcerative colitis (UC) and Crohn's disease (CD). The exact etiology and pathogenesis have not yet been elucidated, and clinically there is no effective treatment. The clinical manifestations of UC are that intestinal damage first appears in the distal colon and sigmoid colon, with persistent dull pain or dull pain in the left lower abdomen, which can be relieved after diarrhea; stools are mostly mucus or pus and blood samples, and may be accompanied by tenesmus. The clinical manifestations of CD are mostly abdominal pain, right l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50
CPCA61K9/5026A61K35/63
Inventor 韩博藏洁陈文马尚智陈海君王秋平秦惠玉唐婷曾涛刘桂花
Owner SHIHEZI UNIVERSITY
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