Supercharge Your Innovation With Domain-Expert AI Agents!

A kind of modified hydroxypropyl methylcellulose sealing glue for hollow capsule and preparation method thereof

A technology of hydroxypropyl methylcellulose and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, and pharmaceutical formulas, etc. Not easy to long-distance transportation and other problems, to achieve the effect of low cost, strong anti-aging ability, good antibacterial effect

Active Publication Date: 2021-02-09
JIANGSU LEFAN CAPSULE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the present invention solves the problem of insufficient sealing after the hard hollow capsule is filled with solid liquid content, it provides a solution to the problem that the smell of the plant source content is volatile and the liquid content is easy to seepage, and provides a hard hollow capsule sealing glue preparation process
However, the sealant has poor weather resistance, is not easy for long-distance transportation, and is not suitable for high-temperature reservoirs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of modified hydroxypropyl methylcellulose sealing glue for hollow capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A modified hydroxypropyl methylcellulose sealant for hollow capsules, comprising modified hydroxypropyl methylcellulose, fillers, absolute ethanol and purified water, modified hydroxypropylmethylcellulose, fillers, no The mass ratio of water ethanol and purified water is 1:15:12:32; the modified hydroxypropyl methylcellulose is composed of hydroxypropylmethylcellulose, sodium alginate, nano-titanium dioxide, hydrophilic macromolecular compound and The composition of purified water has a solid content of 4wt.%.

[0020] The hydrophilic polymer compound is a condensation product of ethylene oxide and acrylic acid, with an average molecular weight of 4000 and a molar ratio of 3:1.

[0021] The filler includes the following components in parts by mass: 1 part of vitamin C, 3 parts of sodium chloride, 2 parts of maltodextrin, 3 parts of glycerin, 10 parts of hydroxypropyl starch and 1 part of pigment.

[0022] The preparation method of modified hydroxypropyl methylcellulose...

Embodiment 2

[0029] A modified hydroxypropyl methylcellulose sealant for hollow capsules, comprising modified hydroxypropyl methylcellulose, fillers, absolute ethanol and purified water, modified hydroxypropylmethylcellulose, fillers, no The mass ratio of water ethanol and purified water is 1.2:22:15:45; the modified hydroxypropyl methylcellulose is composed of hydroxypropylmethylcellulose, sodium alginate, nano-titanium dioxide, hydrophilic macromolecular compound and The composition of purified water has a solid content of 4.5wt.%.

[0030] The hydrophilic polymer compound is a condensation product of ethylene oxide and acrylic acid, with an average molecular weight of 4500 and a molar ratio of 3:1.

[0031] The filler includes the following components in parts by mass: 1.2 parts of vitamin C, 5 parts of sodium chloride, 5 parts of maltodextrin, 7 parts of glycerin, 20 parts of hydroxypropyl starch and 1 part of pigment.

[0032] The preparation method of modified hydroxypropyl methylce...

Embodiment 3

[0039] A modified hydroxypropyl methylcellulose sealant for hollow capsules, comprising modified hydroxypropyl methylcellulose, fillers, absolute ethanol and purified water, modified hydroxypropylmethylcellulose, fillers, no The mass ratio of water ethanol and purified water is 2:28:18:48; the modified hydroxypropyl methylcellulose is composed of hydroxypropylmethylcellulose, sodium alginate, nano-titanium dioxide, hydrophilic macromolecular compound and The composition of purified water has a solid content of 5wt.%.

[0040] The hydrophilic polymer compound is a condensation product of ethylene oxide and acrylic acid, with an average molecular weight of 5000 and a molar ratio of 3:1.

[0041] The filler includes the following components in parts by mass: 2 parts of vitamin C, 8 parts of sodium chloride, 6 parts of maltodextrin, 9 parts of glycerin, 24 parts of hydroxypropyl starch, and 2 parts of pigment.

[0042] The preparation method of modified hydroxypropyl methylcellul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a modified hydroxypropyl methylcellulose sealing glue for hollow capsules and a preparation method thereof. The sealant includes modified hydroxypropyl methylcellulose, filler, absolute ethanol and purified water, and the mass ratio of modified hydroxypropyl methylcellulose, filler, absolute alcohol and purified water is 1‑2:15‑ 28:12-18:32-48; the modified hydroxypropyl methylcellulose is composed of hydroxypropyl methylcellulose, sodium alginate, nano-titanium dioxide, hydrophilic polymer compound and purified water, the solid content It is 4‑5wt.%. The modified hydroxypropyl methylcellulose is firstly prepared, then mixed with absolute ethanol, filler and purified water, and finally left standing to adjust the viscosity. The sealing glue of the invention has strong aging resistance and low cost, and is especially suitable for filling volatile and oxidizable medicines.

Description

technical field [0001] The invention belongs to the technical field of capsule preparation, and in particular relates to a modified hydroxypropyl methylcellulose sealing glue for hollow capsules and a preparation method thereof. Background technique [0002] Capsule sealing means that after the hollow capsule is filled with medicine, one or more layers of coating film are encapsulated at the sealing part of the capsule to form a sealed strip-shaped film coating layer. After the traditional hard hollow capsule is filled with solid liquid content, due to the small gap between the cap and the body joint, the capsule has poor oxidation resistance and is prone to change during storage, and the small gap between the cap and body will increase. Large, it becomes percolation, which leads to the loss of active ingredients in the content to varying degrees. [0003] Application number 201510311313.3, titled as a formulation of hard hollow capsule sealant, discloses the pharmaceutical...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/22A61K47/02
CPCA61K9/4833A61K47/02A61K47/22A61K47/36A61K47/38
Inventor 王飞陈思宇潘恒
Owner JIANGSU LEFAN CAPSULE
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com