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Doxazosin combination

A technology of doxazosin and sazosin tablets, which is applied in drug combination, pill delivery, urinary system diseases, etc. It can solve the problems of decreased solubility of active substances, easy moisture absorption of tablets, and pockmarked appearance of tablets, etc. Achieve the effect of improving the dissolution rate drop, good moisture resistance, and improving content uniformity

Inactive Publication Date: 2018-04-24
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] During the research process of doxazosin ordinary tablets, it was found that doxazosin belongs to small-scale preparations. During the preparation process of ordinary tablets, firstly, the content uniformity is not easy to meet the standard, and secondly, after long-term storage, the tablets are easy to absorb. Moist, the appearance of the tablet is pockmarked and the solubility of the active substance tends to decrease

Method used

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  • Doxazosin combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1. Doxazosin 2 g, corn starch 25 g, sodium carboxymethyl starch 16 g, microcrystalline cellulose 35 g, sodium lauryl sulfate 1.0 g, calcium sulfate 20 g, polyethylene glycol 4000 5 g, stearin Magnesium acid 1.0g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 2

[0021] Embodiment 2. Doxazosin 2 g, corn starch 45 g, sodium carboxymethyl starch 10 g, microcrystalline cellulose 50 g, sodium lauryl sulfate 1.8 g, calcium sulfate 12 g, polyethylene glycol 4000 8 g, stearin Magnesium acid 1.6g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 3

[0022] Embodiment 3. Doxazosin 2 g, corn starch 35 g, sodium carboxymethyl starch 14 g, microcrystalline cellulose 45 g, sodium lauryl sulfate 1.3 g, calcium sulfate 16 g, polyethylene glycol 4000 6.5 g, hard Magnesium fatty acid 1.4g, prepare 1000 tablets by the preparation method described in the technical scheme.

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Abstract

The invention relates to a doxazosin combination, and belongs to the technical field of pharmacy. The doxazosin combination is characterized by being prepared from 2 mg of doxazosin, 25-45 mg of cornstarch, 10-16 mg of sodium carboxymethyl starch, 35-50 mg of microcrystalline cellulose, 1.0-1.8 mg of sodium dodecyl sulfate, 12-20 mg of calcium sulfate, 5-8 mg of polyethylene glycol 4000 and 1.0-1.6 mg of magnesium stearate in the unit dose combination. The doxazosin combination is stable.

Description

technical field [0001] The invention relates to a doxazosin composition and belongs to the technical field of pharmacy. Background technique [0002] Hyperplasia of the prostate, often called benign prostatic hyperplasia (BPH), is one of the common diseases of middle-aged and elderly men, and its incidence is increasing with the aging of the global population. The incidence of benign prostatic hyperplasia increases with age, and most patients have symptoms such as dysuria that increase with age. [0003] Prostatic hypertrophy is also called benign prostatic hyperplasia. Symptoms are mainly manifested in two groups of symptoms, one is bladder irritation symptoms; the other is obstructive symptoms caused by prostatic hyperplasia blocking the urinary tract. Bladder irritation symptoms: urinary frequency, urgency, nocturia, and urge incontinence. Frequent urination is an early signal of benign prostatic hyperplasia, especially the increased frequency of nocturia is more clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/517A61K47/02A61K47/10A61K47/20A61P13/08
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH