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A kind of quality detection method of Hanchuan Zupa preparation

A quality testing method and testing method technology, applied in the field of medical testing, can solve the problems of large Rf value, can not fully reflect the internal quality of Hanchuan Zupa preparation, the determination of main components and active components, and achieve a stable baseline and avoid near-term problems. The effect of greater absorption of UV impurity peaks, reducing the possibility of quality compliance

Active Publication Date: 2021-08-13
XINJIANG CICON HABO WEI PHARMA RES INST
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  • Description
  • Claims
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Problems solved by technology

However, these single-component determinations cannot fully reflect the intrinsic quality of Hanchuan Zupa preparations, and the TLC-identified R f The value is relatively large, and the content of the main components and active components has not been determined at the same time, which is one-sided. How to establish a convenient and comprehensive detection method that contains comprehensive information needs to be solved urgently

Method used

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  • A kind of quality detection method of Hanchuan Zupa preparation
  • A kind of quality detection method of Hanchuan Zupa preparation
  • A kind of quality detection method of Hanchuan Zupa preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049](1) Preparation of the test solution:

[0050] After completely dissolving 0.2g of Hanchuan Zupa granules in 5ml of methanol solution with a mass fraction of 30%, ultrasonically extract for 25min, then filter with a 0.22μm microporous membrane, and the filtrate is the test solution;

[0051] (2) Preparation of reference substance solution:

[0052] After dissolving 1 mg of ammonium glycyrrhizinate in 20 ml of methanol, filter through a 0.22 μm microporous membrane to obtain the reference substance solution;

[0053] (3) Detection:

[0054] Take 10 μl each of the reference solution and the test solution, inject them into a high-performance liquid chromatograph, and record the chromatogram within 68 minutes; wherein, the filler is octadecylsilane bonded silica gel; the mobile phase A is a mass fraction of 0.09 % phosphoric acid solution, the mobile phase B is acetonitrile, the gradient elution method is adopted, the elution flow rate is 1.0ml / min, the volume fraction of ...

Embodiment 2

[0057] (1) Preparation of the test solution:

[0058] After completely dissolving 0.5g of Hanchuan Zupa granules in 5ml of methanol solution with a mass fraction of 70%, ultrasonically extract for 35min, and then filter with a 0.22μm microporous membrane to obtain the test solution;

[0059] (2) Preparation of reference substance solution:

[0060] After dissolving 2 mg of ammonium glycyrrhizinate in 1 ml of methanol, filter through a 0.22 μm microporous membrane to obtain the reference substance solution;

[0061] (3) Detection:

[0062] Take 5 μl each of the reference substance solution and the test solution, inject them into a high-performance liquid chromatograph, and record the chromatogram within 70 minutes; wherein, the filler is octadecylsilane bonded silica gel; the mobile phase A is a mass fraction of 0.11 % phosphoric acid solution, the mobile phase B is acetonitrile, the gradient elution method is adopted, the elution flow rate is 1.0ml / min, the volume fraction o...

Embodiment 3

[0065] (1) Preparation of the test solution:

[0066] After completely dissolving 0.3g of Hanchuan Zupa granules in 5ml of methanol solution with a mass fraction of 50%, ultrasonically extract for 30min, and then filter with a 0.22μm microporous membrane to obtain the test solution;

[0067] (2) Preparation of reference substance solution:

[0068] After dissolving 2 mg of ammonium glycyrrhizinate in 25 ml of methanol, filter through a 0.22 μm microporous membrane to obtain the reference substance solution;

[0069] (3) Detection:

[0070] Take 8 μl each of the reference substance solution and the test solution, inject them into a high-performance liquid chromatograph, and record the chromatogram within 68 minutes; wherein, the filler is octadecylsilane bonded silica gel; the mobile phase A is a mass fraction of 0.10 % phosphoric acid solution, the mobile phase B is acetonitrile, the gradient elution method is adopted, the elution flow rate is 1.0ml / min, the volume fraction ...

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Abstract

The invention relates to a quality detection method of Hanchuan Zupa preparation. The detection method comprises the following steps: (1) preparing a test solution; (2) preparing a reference solution; (3) detecting. The quality detection method of a Hanchuan Zupa preparation according to the present invention, the fingerprint detection method of the Hanchuan Zupa preparation prepared according to the detection method, the HPLC fingerprint of the Hanchuan Zupa preparation established is similar to that of the control spectrum The degrees are greater than 0.9. The established common pattern of the HPLC characteristic fingerprint of Hanchuan Zupa preparation has more peaks, good peak shape, easy identification, high similarity, and relatively complete information reflected. The established fingerprint has high technical content and is accurate. Reliable; the detection method is simple, stable, with high precision and good reproducibility, and can control the quality of Hanchuan Zupa preparation from the overall characteristics to ensure its stable and controllable quality, thereby ensuring the safety of Hanchuan Zupa preparation and effectiveness, providing a scientific basis for the quality control of Hanchuan Zupa preparations.

Description

technical field [0001] The invention belongs to the field of medical testing, and in particular relates to a quality testing method of Hanchuan Zupa preparation. Background technique [0002] Hanchuan Zupa preparations are recorded in the Uyghur medicine sub-volume of "Drug Standards of the Ministry of Health of the People's Republic of China", standard number: WS 3 -BW-0195-98. It was first recorded in "Jamiiraki" compiled by Aikmu Muhammad Nur in 1336. Hanchuan Zupa preparation has the functions of antitussive, phlegm-resolving, lung-warming and asthma-relieving. It is used for acute cold, cough and abnormal mucous asthma caused by cold nature. It is a classic prescription of Uighur medicine for treating colds, and it is widely used among people of all ethnic groups in Xinjiang. Its prescription includes cumin, celery seed, sage herb, rose flower, rue, nettle seed, maidenhair fern, fenugreek, licorice extract. The composition of Hanchuan Zupa preparation is complex, s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/64
CPCG01N30/02G01N30/06G01N30/64
Inventor 陈金成季志红马璇李柯翱
Owner XINJIANG CICON HABO WEI PHARMA RES INST
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