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Method for detecting nimodipine in Chinese patent medicines and health food by virtue of liquid chromatography-mass spectrometry

A health food, LC/MS technology, applied in measuring devices, instruments, scientific instruments, etc., to achieve the effects of less interference, accurate detection results, and high sensitivity

Inactive Publication Date: 2018-06-05
WUZHOU INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, medicines may be illegally added to health foods that assist memory improvement, including nimodipine. Currently, there are few screening methods for illegal addition of traditional Chinese medicine preparations that assist memory improvement and health foods. and health food to detect whether there is nimodipine in order to prevent and supervise the occurrence of adverse events caused by memory-improving Chinese patent medicines and health food after entering the market to ensure safety. It is necessary to establish memory-improving traditional Chinese medicine preparations and rapid screening method for nimodipine in health food

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) prepare reference substance solution: get nimodipine reference substance and dissolve with methanol and be mixed with the nimodipine solution that concentration is 1mg / ml, then get in the 1ml nimodipine solution preparation bottle, be settled to 100ml with methanol, obtain Nimodipine reference substance solution.

[0021] (2) Prepare the sample solution to be tested: the configuration method of the liquid preparation: accurately draw a considerable oral dose, put it in a 50ml measuring bottle, add 20ml of 50% aqueous methanol solution, and ultrasonically process it for 15min at 1130W under the condition of 37kHz, let it cool, and use Dilute 50% aqueous methanol to the mark, shake well, take 1ml of the solution and dilute it 10 times with water, and use it as the test solution for later use.

[0022] The preparation method of the solid preparation: take the test product of the solid preparation and grind it finely, accurately weigh the dose equivalent to one oral dos...

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Abstract

The invention discloses a method for detecting nimodipine in Chinese patent medicines and health food by virtue of liquid chromatography-mass spectrometry. The method comprises the following steps: (1) preparing reference solution, namely taking a nimodipine reference substance and methanol and preparing the reference solution; (2) preparing to-be-detected solution, namely taking traditional Chinese medicinal preparations helping to improve the memory and the health food, extracting by adopting methanol, and purifying solution obtained through extraction, so that the to-be-detected sample solution is obtained; and (3) loading the reference substance solution and the to-be-detected sample solution onto a liquid chromatograph / mass spectrometer, and carrying out qualitative and quantitative determination on nimodipine in test solution. The method disclosed by the invention has the advantages that a multi-reaction monitoring manner is adopted for carrying out detection, interference is low, sensitivity is high and detection result is accurate.

Description

technical field [0001] The invention relates to a method for detecting nimodipine, in particular to a method for detecting nimodipine in Chinese patent medicine and health food by liquid chromatography-mass spectrometry. Background technique [0002] Nimodipine has a nootropic effect, but it is mainly used for Meniere's syndrome, vascular headache and cerebral arteriosclerosis, and can be used for the treatment of acute ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral embolism, transient cerebral Insufficient blood supply, etc.; it is also effective for orthostatic vertigo and tinnitus caused by high blood pressure. However, it can produce side effects such as loss of appetite, nausea, vomiting, dry mouth, headache, heart palpitations, and dermatitis. [0003] In recent years, with the increasing pressure of social competition and the expansion of an aging society, Chinese patent medicines and health care products that help improve memory have a cons...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 陈学松罗达龙刘慧妍
Owner WUZHOU INST FOR FOOD & DRUG CONTROL
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