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Production of in situ crosslinkable polyisobutylene-polyurethane nanofibers and coatings

A polyisobutylene and polyisobutylene diol technology, which can be used in coating, surgery, spinal nerve electrodes, etc., can solve the problems of time-consuming, difficult to manufacture polyisobutylene-polyurethane block copolymers, and solvent-based deposition processing.

Pending Publication Date: 2018-06-08
CARDIAC PACEMAKERS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these physical properties can also make polyisobutylene-polyurethane block copolymer fabrication and solvent-based deposition processing difficult and time-consuming

Method used

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  • Production of in situ crosslinkable polyisobutylene-polyurethane nanofibers and coatings
  • Production of in situ crosslinkable polyisobutylene-polyurethane nanofibers and coatings
  • Production of in situ crosslinkable polyisobutylene-polyurethane nanofibers and coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Polymerization of PIB-PUR in 2,6-Lutidine

[0082] A mixture of 14.3 g of polyisobutylene diol (saturated, 88.8% polyisobutylene) and 6.82 g of polytetramethylene oxide diol was initially mixed with 50 g of toluene. The mixture was heated overnight at a temperature of 70° C. under a nitrogen purge to remove moisture and toluene. The mixture was charged into a 100 ml glass reactor along with 8.57 g methylene diphenyl diisocyanate and 65 g 2,6-lutidine. The mixture was stirred at 150 RPM and maintained at a temperature of 90°C. Agitation is provided by rotating Teflon paddles. After two hours, 0.02 g of tin(II) 2-ethylhexanoate and 3 ml of toluene were added to the reactor. After five minutes, 1.94 g of 1,4-butanediol and another 25 g of 2,6-lutidine were slowly added to the reactor to prevent the solution from containing 2,6-lutidine along with the reactants. Polymerizes in solution to form PIB-PUR and becomes too viscous. After one hour, the PIB-PUR solution is r...

Embodiment 2

[0084] Deposition of PIB-PUR in 2,6-lutidine by electrospinning

[0085] Lithium bromide salt (LiBr) was combined with a mixture of PIB-PUR solutions prepared as described above in Example 1 to form a solution containing 0.1% by weight LiBr. Fill the syringe with the PIB-PUR solution / salt mixture and connect to the nozzle of the electrospinning machine. The PIB-PUR solution / salt mixture was electrospun at a flow rate of 0.3 mL / h onto the electrode coil of a medical electrical lead at a distance of 10 cm from the nozzle tip to form a polymer network on the electrode coil. Environmental conditions included a relative humidity of 34% and a temperature of 23°C. Figure 4 A 1000X magnification image of the thin polymer network of the as-prepared PIB-PUR.

Embodiment 3

[0087] Deposition of PIB-PUR in 2,6-lutidine by spraying

[0088] A mixture of 69.795 g of the PIB-PUR solution prepared as described in Example 1 and another 75 ml of 2,6-lutidine was treated in a centrifuge at 5000 RPM for 20 minutes to dilute the PIB-PUR solution from a viscosity of 0.354 Pa ·s decreased to 0.048Pa·s. The PIB-PUR content was measured as 26.6% before dilution and 15.2% after dilution. Load the diluted PIB-PUR solution into Gravity air brush and spray onto braided inner coils for medical electrical leads. The coil was set on a mandrel rotating at 350 RPM at room temperature and 60.2% relative humidity.

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Abstract

A method for making a device including a polyisobutylene-polyurethane block copolymer is disclosed. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender withina solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Provisional Application No. 62 / 243,057, filed October 17, 2015, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates to medical devices and methods for manufacturing medical devices. More specifically, the present invention relates to methods of making medical devices and medical devices comprising polyisobutylene-polyurethane block copolymer layers. Background technique [0004] Polymeric materials are widely used in the field of implantable medical devices. For example, polymeric materials such as silicone rubber, polyurethane, and fluoropolymers are used as coatings and / or insulation for medical leads, stents, and other devices. [0005] Incorporation of polymeric materials into implantable medical devices can be done in various ways, depending on the specific application. In some applications, for example, fo...

Claims

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Application Information

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IPC IPC(8): C08G18/76C08G18/08A61L31/06C08J3/09C08G18/66C08J7/02C08G18/12C08G18/24C08G18/32
CPCA61L29/085C08G18/6674C08G18/7671C08G18/12C08G18/24C08G18/3206A61L31/10A61L2420/02C08L23/22C08L75/04C08L53/00A61L31/06C08G81/024A61N1/05A61N1/0534A61N1/0541A61N1/0543A61N1/0551A61N1/056A61N1/0507
Inventor 约瑟夫·T·小德兰尼尼拉杰·古隆大卫·R·伍尔夫曼艾德格博拉·O·阿德努希帕特里克·威洛比阿德尼伊·O·阿雷姆
Owner CARDIAC PACEMAKERS INC
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