Unlock instant, AI-driven research and patent intelligence for your innovation.

Application and pharmaceutical preparation of sipratin in pharmacy

A technology of ceretin and medicine, which is applied to the application of ceretin in pharmacy and the field of pharmaceutical preparations, can solve the problem of high fatality rate and achieve the effect of good drug efficacy

Active Publication Date: 2020-07-10
WUHAN NORJAN BIOLOGICAL TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the incidence of AHS is only 0.1%, the fatality rate is as high as 20%.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Verification of the effect of sipratin on inhibiting xanthine oxidase activity

[0027] Xanthine Oxidase (XO, EC 1.17.3.2) is a highly specific enzyme that can not only catalyze hypoxanthine to xanthine, and then uric acid, but also directly catalyze xanthine to uric acid. The invention proves that sipratin inhibits the activity of xanthine oxidase to prevent or treat hyperuricemia.

[0028] Allopurinol is a urate-lowering drug widely used at present. Allopurinol is a competitive xanthine oxidase inhibitor, which produces urate-lowering effect by inhibiting uric acid synthesis. Adverse reactions of allopurinol mainly include gastrointestinal symptoms, rash, liver function damage, bone marrow suppression, etc., and should be monitored. About 5% of patients cannot tolerate it. Severe allopurinol hypersensitivity syndrome (allopurinol hypersen sitivity syndrome, AHS) occasionally occurs. The risk is increased in patients with renal insufficiency and with thia...

Embodiment 2

[0062] Example 2 Verification of the uric acid-lowering activity of sipratin

[0063] Allopurinol is a urate-lowering drug widely used at present. Allopurinol is a competitive xanthine oxidase inhibitor, which produces urate-lowering effect by inhibiting uric acid synthesis. Adverse reactions of allopurinol mainly include gastrointestinal symptoms, rash, liver function damage, bone marrow suppression, etc., and should be monitored. About 5% of patients cannot tolerate it. Severe allopurinol hypersensitivity syndrome (allopurinol hypersen sitivity syndrome, AHS) occasionally occurs. The risk is increased in patients with renal insufficiency and with thiazide diuretics. Khanna and other studies have confirmed that AHS is closely related to the leukocyte antigen HLA-B5801 gene positivity. The HLA-B58 positive rate of Chinese Han people is 6% to 8%, while that of white people is only 2%. Although the incidence of AHS is only 0.1%, the case fatality rate is as high as 20%. In...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of daphnoretin in pharmacy and a pharmaceutic preparation, application of daphnoretin or medically acceptable salt and solvent compounds in the preparation of drugspreventing and / or treating hyperuricemia. The invention aims at providing a drug which is low in cost, good in efficacy, is able to prevent and / or treate hyperuricemia and a drug of gout caused by the hyperuricemia.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application and pharmaceutical preparation of sipratin in pharmacy. Background technique [0002] With the improvement of people's living standards and changes in eating habits, the incidence of hyperuricemia and gout in my country has been increasing year by year in recent years. Hyperuricemia is a disease in which blood uric acid exceeds the normal value due to purine metabolism disorder and / or uric acid excretion disorder. It refers to the level of blood uric acid on an empty stomach twice on different days under a normal purine diet: male > 420 μmol / L, Women >360μmol / L, no clinical symptoms. When the human body is in the condition of hyperuricemia for a long time, uric acid is precipitated in the joints, soft tissues, cartilage and kidneys in the form of sodium salt, causing human organ and tissue lesions, leading to gout, and causing serious complications, including g...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P19/06
CPCA61K31/37
Inventor 赵玲杨博邵萌陈新刘梁
Owner WUHAN NORJAN BIOLOGICAL TECH