New anti-tumor compound obtained through sulfation
An anti-tumor and sulfation technology, applied in anti-tumor drugs, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of long development cycle of chemically synthesized drugs, restricting drug development and application, and large clinical side effects. , to achieve the effect of enhancing phagocytosis, enhancing the ability to resist diseases, and strengthening immune function
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Embodiment 1
[0016] Embodiment 1: A kind of novel antitumor compound obtained by sulfation, the preparation method is:
[0017] (1) Take 100g of dried black ganoderma lucidum, add 95% ethanol to soak and extract at room temperature for 48 hours, filter, repeat once, put the medicinal residue in a ventilated place at room temperature to dry, and then compare the medicinal residue with distilled water according to the mass volume (kg / L) Mix at a ratio of 1:20, reflux and extract twice, each extraction time is 2h, 1h in turn, combine the extracts, centrifuge, concentrate under reduced pressure; the obtained sample is added with an appropriate amount of 95% ethanol to make the volume fraction of ethanol in the solution was 80%, and then precipitated, stood at 4°C for 24 hours, and centrifuged; the precipitates were combined, washed with absolute ethanol, absolute ether, and acetone in turn, and freeze-dried to obtain samples; the obtained dry samples were measured by Sevag Protein removal meth...
Embodiment 2
[0022] Embodiment 2: A novel antitumor compound obtained by sulfation, the preparation method is:
[0023] (1) Take 100g of dried black ganoderma lucidum, add 95% ethanol to soak and extract at room temperature for 48 hours, filter, repeat once, put the medicinal residue in a ventilated place at room temperature to dry, and then compare the medicinal residue with distilled water according to the mass volume (kg / L) Mix at a ratio of 1:20, reflux and extract twice, each extraction time is 2h, 1h in turn, combine the extracts, centrifuge, concentrate under reduced pressure; the obtained sample is added with an appropriate amount of 95% ethanol to make the volume fraction of ethanol in the solution was 80%, and then precipitated, stood at 4°C for 24 hours, and centrifuged; the precipitates were combined, washed with absolute ethanol, absolute ether, and acetone in turn, and freeze-dried to obtain samples; the obtained dry samples were measured by Sevag Protein removal method, that...
Embodiment 3
[0028]Embodiment 3: A kind of novel antitumor compound obtained by sulfation, the preparation method is:
[0029] (1) Take 100g of dried black ganoderma lucidum, add 95% ethanol to soak and extract at room temperature for 48 hours, filter, repeat once, put the medicinal residue in a ventilated place at room temperature to dry, and then compare the medicinal residue with distilled water according to the mass volume (kg / L) Mix at a ratio of 1:20, reflux and extract twice, each extraction time is 2h, 1h in turn, combine the extracts, centrifuge, concentrate under reduced pressure; the obtained sample is added with an appropriate amount of 95% ethanol to make the volume fraction of ethanol in the solution was 80%, and then precipitated, stood at 4°C for 24 hours, and centrifuged; the precipitates were combined, washed with absolute ethanol, absolute ether, and acetone in turn, and freeze-dried to obtain samples; the obtained dry samples were measured by Sevag Protein removal metho...
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