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A kind of method utilizing microorganism to synthesize p-hydroxybenzaldehyde

A technology for synthesizing p-hydroxybenzaldehyde and microorganisms, which can be applied to microorganism-based methods, biochemical equipment and methods, microorganisms, etc., can solve problems such as high cost, environmental pollution, and low yield, and achieve low pollution and low energy consumption. , the preparation method is simple

Active Publication Date: 2021-04-13
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the industrial production of p-hydroxybenzaldehyde is mainly synthesized from o-hydroxybenzyl alcohol, o-hydroxybenzoic acid, phenol, and o-cresol as raw materials, and there are mainly the following problems: high cost, low yield, and serious environmental pollution Wait

Method used

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  • A kind of method utilizing microorganism to synthesize p-hydroxybenzaldehyde
  • A kind of method utilizing microorganism to synthesize p-hydroxybenzaldehyde
  • A kind of method utilizing microorganism to synthesize p-hydroxybenzaldehyde

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Embodiment Construction

[0039] The technical solution of the present invention will be further analyzed and illustrated through specific examples below.

[0040] The method that the present invention utilizes microorganism to synthesize p-hydroxybenzoic acid is as follows:

[0041] 1. Preparation of raw materials

[0042] 1a. The strain Gongronella sp.w5 was isolated from the soil. The strain has been preserved in the China Center for Type Culture Collection, date of preservation: December 30, 2017, preservation number CCTCC NO: M 2017787. .

[0043] 1b. Preparation of solid CPDA medium: Mix 20% potato filtrate, 20g glucose, 3.0g potassium dihydrogen phosphate, 1.5g magnesium sulfate heptahydrate, 0.04g vitamin B1 and 15g agar powder, and then sterilize at 115°C. Bacteria for 30min, set aside.

[0044] 1c. Preparation of the VI liquid medium: 15g sucrose, 1.5g DL-asparagine, 1.0g potassium dihydrogen phosphate, 0.5g magnesium sulfate heptahydrate, 0.1g disodium hydrogen phosphate dodecahydrate, 0....

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Abstract

The invention discloses a method for synthesizing p-hydroxybenzaldehyde by using microorganisms. The soil-derived fungal strain Gongronella sp.w5 is used as a production bacterium, and the p-hydroxybenzaldehyde is obtained by extracting and separating from its fermentation liquid. Compared with the chemical synthesis method, the whole reaction process of the present invention is carried out at normal temperature and pressure, with less pollution, less energy consumption, simple preparation method, no need for phenolic substances as raw materials, and the purity of the target product is greater than 98%.

Description

technical field [0001] The invention relates to a method for using microorganisms to synthesize p-hydroxybenzaldehyde. Background technique [0002] p-Hydroxybenzaldehyde (p-Hydroxybenzaldehyde) is an important intermediate substance, which is widely used in the fields of medicine, fragrance, pesticide and petrochemical industry. In terms of medicine, p-hydroxybenzaldehyde can be used to synthesize drugs such as amoxicillin (amoxicillin), antibacterial synergist trimethoprim (TMP), cardiovascular and cerebrovascular drug Esmolol, p-hydroxyglycine and artificial Gastrodia elata; In terms of spices, p-hydroxybenzaldehyde can be used to synthesize many precious spices such as vanillin, jasminaldehyde, anisaldehyde, syringaldehyde and raspberry ketone; in terms of pesticides, p-hydroxybenzaldehyde can be used to synthesize high-efficiency herbicides bromoxynil and Hydroxychlornil; in addition, p-Hydroxybenzaldehyde can also be used in the production of fungicides, food and feed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/24C12N1/14C07C45/79C07C47/565C12R1/645
CPCC07C45/79C12N1/14C12P7/24C07C47/565
Inventor 方泽民胡俊房伟肖亚中
Owner ANHUI UNIVERSITY