Pharmaceutical composition containing decoquinate and application of pharmaceutical composition

A technology containing decoquinate and decoquinate, which is applied in the field of pharmaceutical compositions containing decoquinate, can solve the problems of reduced therapeutic effect of antibacterial drugs, and achieve low production cost, low drug resistance and high therapeutic effect Good results

Pending Publication Date: 2018-08-10
JIANGSU LINGYUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the long-term use of antibacterial drugs and E. coli vaccines has also continuously increased the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0018] Example 1

[0019] First, weigh the following raw materials according to the mass: 0.2kg of decoquinate, 0.12kg of mountain bean root, 0.1kg of stearic acid, 0.03kg of n-butanol, 0.07kg of aminobenzoic acid, and 0.05kg of isopropyl myristate; Surfactant stearic acid, co-surfactant n-butanol, co-solvent aminobenzoic acid and isopropyl myristate were stirred and mixed evenly with a glass rod, and then added decoquinate and shandougen in sequence, and then used a mixer After stirring and mixing uniformly, add 0.48kg of deionized water and put it in an ultrasonic cleaner with a power of 120W and ultrasonic for 5 hours until a uniform and transparent solution is formed; finally, it is moved into a vacuum drying oven at 55°C and dried for 4.5 hours to obtain a decoquine Pharmaceutical composition.

Example Embodiment

[0020] Example 2

[0021] First, weigh the following raw materials according to the mass: 0.23 kg of decoquinate, 0.17 kg of lecithin 0.13 kg of mountain bean root, 0.06 kg of n-pentanol, 0.1 kg of acetamide, and 0.08 kg of jojoba oil; then the surfactant lecithin, Co-surfactant n-pentanol, co-solvent acetamide and jojoba oil were stirred and mixed uniformly with a glass rod, then decoquinate and shandougen were added in sequence, and then mixed with a mixer, and then 0.8kg deionized water was added Put it into an ultrasonic cleaner with a power of 140W and sonicate it for 6 hours until a uniform and transparent solution is formed; finally, it is moved into a 60°C vacuum drying oven and dried for 5 hours to obtain a pharmaceutical composition containing decoquinate.

Example Embodiment

[0022] Example 3

[0023] First, weigh the following raw materials according to the mass: 0.28kg of decoquinate, 0.22kg of mountain pea root, 0.16kg of Tween-20, 0.08kg of isopropanol, 0.13kg of sodium salicylate, and 0.09kg of isopropyl myristate; Then the surfactant Tween-20, the co-surfactant isopropanol, the co-solvent sodium salicylate and the oil isopropyl myristate are stirred and mixed uniformly with a glass rod, and then the decoquinate and shandougen are sequentially added , And then use a mixer to mix evenly, add 1.0kg deionized water and put it in a 160W ultrasonic cleaner, ultrasonic for 7 hours, until a uniform and transparent solution is formed; finally, it is moved into a 70 ℃ vacuum drying oven and dried for 6 hours. Pharmaceutical composition of quinoate.

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing decoquinate. The composition is prepared from the following components in parts by weight: 20-45 parts of decoquinate, 10-32 parts of radix sophorae subprostratae, 8-21 parts of surfactant, 0-15 part of co-surfactant, 5-18 parts of cosolvent and 4-15 parts of oil; the composition is prepared by the steps of evenly mixing the surfactant, the co-surfactant, the cosolvent and the oil, then sequentially adding the decoquinate and the radix sophorae subprostratae into the mixture, evenly stirring and mixing and then adding deionized water, and carrying out ultrasonic treatment until a uniform and transparent solution is formed; finally, drying to prepare the pharmaceutical composition containing decoquinate. The invention also discloses application of the composition in treatment of poultry colibacillosis. The pharmaceutical composition has the advantages of being good in treatment effect, less in drug residue, low in drug resistance, low in toxic and side effects, and the like; furthermore, the pharmaceutical composition is low in production cost and environmentally friendly, thus being suitable for clinical production andapplication.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a pharmaceutical composition containing decoquinate and application thereof. Background technique [0002] Decoxyquinate is white or off-white crystalline powder, slightly soluble in ethanol and insoluble in water. It mainly exerts its medicinal effect by inhibiting the development of sporozoites in the early stage and killing early schizonts in the middle stage. [0003] Shandougen is a leguminous plant, and its medicinal part is the root. It is a commonly used clinical traditional Chinese medicine. It is mainly produced in the southwest to northwest of Guangxi, and a small amount is also distributed in Guangdong, Yunnan and Guizhou. Shandou root is cold in nature, bitter in taste, and poisonous. It has the effects of clearing heat and detoxification, reducing swelling and relieving throat. It is mainly used for symptoms such as fire and poison accumulatio...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K31/47A61K47/44A61K47/14A61P31/04
CPCA61K31/47A61K36/489A61K47/14A61K47/44A61P31/04A61K2300/00
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA
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