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Antitumor pharmaceutical composition and use thereof

A composition and drug technology, applied in the field of pharmaceutical compositions of anti-tumor drugs, can solve the problems of drug resistance and the like

Active Publication Date: 2020-12-18
SHENZHEN CILISHENG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a pharmaceutical composition of anti-tumor drugs and its use, aiming to solve the problem that artemisinin and its derivatives need to be used at a higher dose to have a better anti-tumor effect, and drug resistance will occur. sexual problems

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  • Antitumor pharmaceutical composition and use thereof
  • Antitumor pharmaceutical composition and use thereof
  • Antitumor pharmaceutical composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Inhibitory effect of an antineoplastic pharmaceutical composition on osteosarcoma cells

[0036] Cell lines and cell culture: The cells used in the experiment include osteosarcoma cells MG-63, MNNG / HOS and U2OS. The culture conditions of all cells are: in a carbon dioxide incubator at 37°C, saturated humidity, and a carbon dioxide content of 5%, grow in DMEM medium containing 10% fetal bovine serum and 1% double antibody, MG-63 and MNNG / HOS was passaged every two days, U2OS was passaged every four days, and the medium was changed once in between.

[0037] Cells in the logarithmic phase were collected and prepared into 5×10 4 cells / mL of single-cell suspension. The cell suspension was inoculated into 96-well culture plates at 100 uL per well, and after culturing in a carbon dioxide incubator for 24 hours, the original culture medium was discarded. Add medium containing different concentrations of dihydroartemisinin (DHA, 0-1280uM) and 100uM ferric ammonium citrate, s...

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Abstract

The invention provides an antineoplastic pharmaceutical composition. The antineoplastic pharmaceutical composition is composed of at least one artemisinin and derivatives of the artemisinin, at leastone iron preparation, and ascorbic acid. According to the antineoplastic pharmaceutical composition, by adding the ascorbic acid and the iron preparation into the artemisinin and the derivatives of the artemisinin, the antineoplastic effects of the artemisinin and the derivatives of the artemisinin can be improved, dosage of the artemisinin and the derivatives of the artemisinin can be reduced, and further toxicity and drug resistance led by the artemisinin and the derivatives of the artemisinin to cells can be reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition of antitumor drugs and its application. Background technique [0002] Artemisinin and its derivatives (such as dihydroartemisinin, artesunate and other sesquiterpenoids containing internal peroxide bridge structure) are clinically effective antimalarial drugs. At the same time, artemisinin And its derivatives have anti-tumor effect. Artemisinin and its derivatives are used as anti-tumor drugs, which have the advantages of a broad anti-tumor spectrum, and can be widely used in various malignant tumors including but not limited to bone cancer, liver cancer, gastric cancer, esophageal cancer, colorectal cancer, leukemia, etc. Treatment. However, there are still deficiencies in the use of artemisinin and its derivatives, mainly in that artemisinin and its derivatives need a higher dose to have a better anti-tumor effect. In additi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61P35/00A61P35/04A61K31/366A61K31/357A61K31/375
CPCA61K31/357A61K31/366A61K31/375A61K33/26A61P35/00A61P35/04A61K2300/00
Inventor 商澎沈颖李鑫张斌尹大川贾斌
Owner SHENZHEN CILISHENG TECH CO LTD