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Extraction and purification technology of nerve cell injury repairing effective part

A technology for nerve cell damage and effective parts, which is applied in the field of biomedicine and can solve problems such as adverse reactions

Inactive Publication Date: 2018-08-17
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anticonvulsants, opioids, and antidepressants are often used for treatment, but most products are not specific for neuropathic pain, and most of them are ineffective or only moderately relieve pain for most patients, and can cause adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Extraction and purification of effective parts for repairing nerve cell damage in formulas of iris, viburnum and safflower

[0025] (1) Take 8 parts by weight of iris, 2 parts by weight of viburnum, and 1 part by weight of safflower, mix and pulverize them into coarse powder, use 95% ethanol as solvent to extract 3 times, soak and extract at room temperature for 4 hours each time, the dosage of 95% ethanol It is 12 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract A; the extracted medicinal residues are then extracted twice with 50% ethanol as a solvent, and each heating and reflux extraction is 1.5 hours, and the amount of 50% ethanol is the total weight of the medicinal materials. 10 times of that, filtered, combined filtrates to obtain extract B; the extracted dregs were then heated to reflux with water as solvent for extraction for 1.5 hours, filtered, combined filtrates to obtain extract E...

Embodiment 2

[0033] Example 2: Extraction and purification of effective parts for repairing nerve cell damage in formulas of iris, viburnum and safflower

[0034] (1) Take 5 parts by weight of iris, 6 parts by weight of viburnum, and 1 part by weight of safflower, mix well and pulverize them into coarse powder, extract 3 times with 95% ethanol as solvent, soak and extract at room temperature for 4 hours each time, the dosage of 95% ethanol It is 12 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract A; the extracted medicinal residues are then extracted twice with 50% ethanol as a solvent, and each heating and reflux extraction is 1.5 hours, and the amount of 50% ethanol is the total weight of the medicinal materials. 10 times of that, filtered, combined filtrates to obtain extract B; the extracted dregs were then heated to reflux with water as solvent for extraction for 1.5 hours, filtered, combined filtrates to obtain extrac...

Embodiment 3

[0042] Example 3: Extraction and purification of effective parts of nerve cell damage repair in the formula of iris, viburnum and safflower

[0043] (1) Take 6 parts by weight of iris, 3 parts by weight of viburnum, and 2 parts by weight of safflower, mix and pulverize them into a coarse powder, use 95% ethanol as the solvent to extract 3 times, soak and extract at room temperature for 4 hours each time, the amount of 95% ethanol It is 12 times of the total weight of the medicinal materials, filtered, and the filtrates are combined to obtain the extract A; the extracted medicinal residues are then extracted twice with 50% ethanol as a solvent, and each heating and reflux extraction is 1.5 hours, and the amount of 50% ethanol is the total weight of the medicinal materials. 10 times of that, filtered, combined filtrates to obtain extract B; the extracted dregs were then heated to reflux with water as solvent for extraction for 1.5 hours, filtered, combined filtrates to obtain ext...

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PUM

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Abstract

The invention discloses an extraction and purification technology of a nerve cell injury repairing effective part. The extraction and purification technology of the nerve cell injury repairing effective part is characterized in that the nerve cell injury repairing effective part is prepared by the following steps: with iris tectorum, viburnum dilatatum and flos carthami as raw mtaerials, performing extraction, separation and purification to obtain the nerve cell injury repairing effective part consisting of spirioidotectal F, spirioidotectal B, vibsatin A, saffloflavoneside A and saffloflavoneside B.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a technology for extracting and purifying effective parts of nerve cell damage repair, in particular to a technology for extracting and purifying effective parts of nerve cell damage repair in a formula composed of iris, viburnum and safflower. Background technique [0002] Traditional Chinese medicine comes from plants, animals, and minerals, and is an important part of medicine. As early as the early Shang Dynasty, people extracted and prepared effective parts from traditional Chinese medicines for disease prevention and treatment, such as oral administration or external application of traditional Chinese medicine decoction; the Ming Dynasty "Compendium of Materia Medica" recorded in detail the process of preparing and purifying camphor by sublimation method; "Bai Yuan Ji" describes the method of extracting and separating crystalline aconitine from fresh Aconitum aconitum; "Introduction...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P25/28A61K31/7048
CPCA61K36/88A61K31/7048A61K36/286A61K36/35A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P25/28A61K2300/00
Inventor 刘燕琳李振山王少华李俊福
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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