Catecholamine solid-phase extraction functional composite material and its preparation method and application

A technology of functional composite materials and catecholamines, applied in the direction of analysis of materials, material separation, chemical instruments and methods, etc., can solve problems such as endangering human health and destruction of hormone balance, achieve wide applicability, reduce consumption of organic solvents, and improve specificity The effect of adsorption performance

Active Publication Date: 2021-01-26
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, consumers do not understand the "mystery" before and during use, which leads to the destruction of hormone balance in the body and causes various diseases
Therefore, adding catecholamines to cosmetics will seriously endanger human health.

Method used

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  • Catecholamine solid-phase extraction functional composite material and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Preparation of catecholamine solid-phase extraction functional composite materials

[0040] (1) Preparation of Fe by chemical co-precipitation method 3 o 4 magnetic nanoparticles

[0041] 10.6g FeCl 3 ·6H 2 O, 4.0 g FeCl 2 4H 2 0 was placed in a three-necked flask filled with 200mL deionized water, ultrasonically dissolved, stirring was started, and N 2 Remove oxygen, heat to 80°C, add 25mL concentrated ammonia water, react for 6h, separate the product from the solution with a strong magnet, and wash Fe with deionized water 3 0 4 To neutrality, add 15mL water to disperse to get black Fe 3 0 4 Ferrofluid (i.e. Fe 3 o 4 magnetic nanoparticles);

[0042] (2) Preparation of 3D graphene

[0043] Take 10mL of 2mg / mL graphene oxide to disperse evenly by ultrasonic, seal it in a 20mL polytetrafluoroethylene-lined high-temperature reactor at 180°C for 12h, cool to room temperature, take out the 3D graphene, and dry the surface moisture with filter paper. save; ...

Embodiment 2

[0057] 1. Preparation of catecholamine solid-phase extraction functional composite materials

[0058] Step (1) (2) is the same as embodiment 1.

[0059] (3) 3D graphene modified Fe 3 o 4 magnetic nanoparticles

[0060] Take 200mg of 3D graphene and place it in a three-neck flask, add 100mL of distilled water, mix it with ice-water bath ultrasound for 10min, stir at 300rpm, take 2000mg of Fe 3 o 4 Magnetic nanoparticles, 100mL distilled water, ultrasonic 3min, add dropwise into a three-necked flask, fill with N 210min, react at room temperature for 1h, separate the product from the solution with a strong magnet, wash with absolute ethanol three times, add 15mL of absolute ethanol to disperse, and obtain a black 3D graphene magnetic fluid.

[0061] (4) Preparation of thiolated 3D graphene magnetic nanoparticles

[0062] Take 600mg of 3D graphene magnetic nanoparticles and place them in a three-necked flask, add 100mL of absolute ethanol, 4mmol of ethyl orthosilicate, ultra...

Embodiment 3

[0069] 1. Preparation of catecholamine solid-phase extraction functional composite materials

[0070] Step (1) (2) is the same as embodiment 1.

[0071] (3) 3D graphene modified Fe 3 o 4 magnetic nanoparticles

[0072] Take 300mg of 3D graphene and place it in a three-neck flask, add 150mL of distilled water, mix with ice-water bath ultrasound for 10min, stir at 300rpm, take 3000mg of Fe 3 o 4 Magnetic nanoparticles, 150mL distilled water, ultrasonic 3min, added dropwise into a three-necked flask, filled with N 2 10min, react at room temperature for 1h, separate the product from the solution with a strong magnet, wash with absolute ethanol three times, add 15mL of absolute ethanol to disperse, and obtain a black 3D graphene magnetic fluid.

[0073] (4) Preparation of thiolated 3D graphene magnetic nanoparticles

[0074] Take 900mg of 3D graphene magnetic nanoparticles and place them in a three-necked flask, add 150mL of absolute ethanol, 6mmol of ethyl orthosilicate, ult...

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Abstract

The invention discloses a solid-phase catecholamine extraction functional composite material with magnetic 3D graphene nanoparticles as a core. A functional polymer, which is arranged on the surface of the solid-phase catecholamine extraction functional composite, is mainly synthesized from ethyl orthosilicate, trimethoxysilylpropanethiol and atropic acid, has a specific affinity site for catecholamines and is of a crosslinked network-like structure. Accordingly, the invention also provides a corresponding preparation method. The solid-phase extraction functional composite material is used foradsorption and dynamic extraction and separation of catecholamines such as trace adrenaline, which are illegally added in the pretreatment of cosmetic samples with complex matrix, and can be appliedto rapid separation and detection of catecholamines. The preparation method is simple, the cost is low, the recovery rate is high, the relative standard deviation is small, and the method has the characteristics of less use of organic solvents and convenient, fast and efficient solid phase extraction operation.

Description

technical field [0001] The invention belongs to the technical field of cosmetics safety detection, and in particular relates to a catecholamine solid-phase extraction functional composite material and a preparation method and application thereof. Background technique [0002] Catecholamine is a neurological substance containing catechol and amine groups. Epinephrine, norepinephrine, and isoproterenol are banned catecholamine substances in cosmetics. Adding one or more of these substances to cosmetics can be To a certain extent, it has the effects of preventing skin aging, removing wrinkles, and increasing skin elasticity, but excessive use will affect the blood circulation of major organs such as the central nervous system, heart and kidney, and cause ischemic symptoms and functional damage of various systems. Therefore, the European Union implemented new cosmetic hygiene standards in 2008, stipulating that such drugs are prohibited substances. The "Hygienic Standards for C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/28B01J20/285B01J20/30G01N30/02G01N30/06
CPCB01J20/28009B01J20/285G01N30/02G01N30/06
Inventor 李小燕刘莉吴宗远王芳刘敏朱晨谭学才雷福厚
Owner GUANGXI UNIV FOR NATITIES
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