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Tilmicosin slow-release enteric agent and preparation method thereof

A technology of tilmicosin and enteric solvents, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor reproducibility between batches of product quality, long batch operation time, Low drying efficiency and other problems, to achieve high uniformity, high bioavailability and good effect

Active Publication Date: 2018-09-04
江西派尼生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has the disadvantages of high labor intensity, low drying efficiency, long batch operation time, low yield of finished products, and poor reproducibility of product quality between batches.

Method used

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  • Tilmicosin slow-release enteric agent and preparation method thereof
  • Tilmicosin slow-release enteric agent and preparation method thereof
  • Tilmicosin slow-release enteric agent and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0030] The present embodiment provides a kind of tilmicosin sustained-release enteric solution, and its formula is as follows:

[0031] Tilmicosin 23kg, Povidone K30 solution (Povidone: purified water=1:4.5) 20kg, carrier (corn starch 72kg), green coating agent solution (green coating agent: purified water=5:1) 30kg.

Embodiment 2

[0033] The present embodiment provides a kind of tilmicosin sustained-release enteric solution, and its formula is as follows:

[0034] Tilmicosin 23kg, Povidone K30 solution (Povidone: purified water=1:4.5) 20kg, carrier (microcrystalline cellulose 30kg, sodium carboxymethyl starch 6kg, cornstarch 72kg), green coating agent solution (Green coating agent: purified water=5:1) 30kg.

Embodiment 3

[0036] The present embodiment provides a kind of tilmicosin sustained-release enteric solution, and its formula is as follows:

[0037] Tilmicosin 23kg, Povidone K30 solution (Povidone: purified water=1:4.5) 20kg, carrier (microcrystalline cellulose 24kg, sodium carboxymethyl starch 10kg, cornstarch 35kg), green coating agent solution (Green coating agent: purified water=5:1) 30kg.

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Abstract

The invention relates to the field of veterinary drugs, in particular to a tilmicosin slow-release enteric agent and a preparation method thereof. The tilmicosin slow-release enteric agent is preparedfrom, by weight, 20-25 parts of tilmicosin, 1-3 parts of povidone and 65-80 parts of carrier; the carrier is selected from one or more of flour, corn starch, microcrystalline cellulose, sodium carboxymethyl starch and hydroxypropyl methyl cellulose. Accordingly, by improving the formula and preparation technology of the tilmicosin slow-release enteric agent, the tilmicosin slow-release enteric agent is prepared by adopting an extrusion-spheronization technology, the coating rate is larger than 99.99%, the bitter taste of tilmicosin can almost be covered completely, gastric acid reaching the stomach does not overflow, the purpose that the enteric agent is released at the intestinal tract after being eaten by a pig, the dwell time of the drug at the intestinal tract is prolonged, the slow-release effect is achieved, and the phenomenon that nausea and vomiting occur after the pig eat the drug is avoided.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a tilmicosin slow-release enteric solution and a preparation method thereof. Background technique [0002] At present, only tilmicosin powder, pellets, and injections are available in domestic and foreign dosage forms. These dosage forms are not only costly, but also inconvenient to administer. The premix is ​​an oral multi-dose dosage form, which is not only convenient for administration, but also has a uniform absorption rate in the body and small differences in bioavailability among individuals. In order to solve the problems that tilmicosin is unstable in acidic environment, easy to be destroyed in the stomach when taken orally, and the drug tastes bitter, tilmicosin’s strong antibacterial activity and superior pharmacokinetic characteristics make it sensitive to livestock and poultry. It has played an important role in the prevention and treatment of pneumonia, pasteurell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K31/43A61K9/52A61K47/38A61K47/32A61P31/04
CPCA61K9/5047A61K31/43A61K31/706A61K47/32A61P31/04A61K2300/00
Inventor 谢艳霞章昭琳易彦洋曾繁山
Owner 江西派尼生物药业有限公司