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Scald restoration medicine

A technology of repairing regeneration and parts by weight, which is applied in the field of medicine, can solve the problems of long healing time of wound surface, cell activity damage, long liquefaction period, etc., and achieve the effect of improving the microenvironment of cell growth, promoting angiogenesis, and restoring activity

Inactive Publication Date: 2018-09-04
CHANGZHOU AMANTE CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to solve the problems that current scald medicines are slow in relieving pain, have a long liquefaction period, and take a long time to heal the wound surface. A medicine for repairing burns

Method used

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  • Scald restoration medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Adipose tissue: porcine adipose stem cells, derived from fresh tissue taken from healthy pigs.

[0031]HG-DMEM cell culture medium: purchased from Gibco, USA.

[0032] Tanshinone Ⅱ A, Danshensu, paeonol: purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.

[0033] Ligustraline: purchased from Chengdu Hengfa Pharmaceutical Co., Ltd.; sinomenine: purchased from Baoji Yongjia Natural Plant Development Co., Ltd.

[0034] Cell repair and regeneration aids: (1) Take adipose tissue and add PBS buffer at a mass ratio of 1:10, centrifuge at 10,000r / min for 5min, discard the middle layer, combine the supernatant and the precipitate to obtain a mixture, and take the mixture at a mass ratio of 100 : 1:1 Add type Ⅰ collagenase and trypsin, enzymolyze at 35°C for 30 minutes, inactivate the enzyme, and obtain the enzymatic hydrolyzate;

[0035] (2) Take HG-DMEM cell culture medium and add sodium bicarbonate and deionized water at a mass ratio of 10:3:80, stir and mix f...

Embodiment 2

[0041] Adipose tissue: porcine adipose stem cells, derived from fresh tissue taken from healthy pigs.

[0042] HG-DMEM cell culture medium: purchased from Gibco, USA.

[0043] Tanshinone Ⅱ A, Danshensu, paeonol: purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.

[0044] Ligustraline: purchased from Chengdu Hengfa Pharmaceutical Co., Ltd.; sinomenine: purchased from Baoji Yongjia Natural Plant Development Co., Ltd.

[0045] Cell repair and regeneration aids: (1) Take adipose tissue and add PBS buffer at a mass ratio of 1:10, centrifuge at 10,000r / min for 10 minutes, discard the middle layer, combine the upper layer and the precipitate to obtain a mixture, and take the mixture at a mass ratio of 100 : 1:1 Add type Ⅰ collagenase and trypsin, enzymolyze at 38°C for 40 minutes, inactivate the enzyme, and obtain the enzymatic hydrolyzate;

[0046] (2) Take HG-DMEM cell culture medium and add sodium bicarbonate and deionized water at a mass ratio of 10:3:80, stir an...

Embodiment 3

[0052] Adipose tissue: porcine adipose stem cells, derived from fresh tissue taken from healthy pigs.

[0053] HG-DMEM cell culture medium: purchased from Gibco, USA.

[0054] Tanshinone Ⅱ A, Danshensu, paeonol: purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.

[0055] Ligustraline: purchased from Chengdu Hengfa Pharmaceutical Co., Ltd.; sinomenine: purchased from Baoji Yongjia Natural Plant Development Co., Ltd.

[0056] Cell repair and regeneration aids: (1) Take adipose tissue and add PBS buffer at a mass ratio of 1:10, centrifuge at 10,000r / min for 7.5min, discard the middle layer, combine the upper layer and the precipitate to obtain a mixture, and take the mixture according to the mass ratio Add type Ⅰ collagenase and trypsin at a ratio of 100:1:1, enzymolyze at 36.5°C for 35 minutes, inactivate the enzyme, and obtain the enzymatic hydrolyzate;

[0057] (2) Take HG-DMEM cell culture medium and add sodium bicarbonate and deionized water at a mass ratio ...

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Abstract

The invention discloses scald restoration medicine, which belongs to the technical field of medicine. The scald restoration medicine adopts fat tissues as a raw material, the type-I collagenase and trypsin are added to digest some mature fat cells through separation and culture, the scald restoration medicine has high self renewability, multidirectional differentiation capability and cross-germ-layer development plasticity, and has an effect for proliferating differentiating epidermis cells, fiber-forming cells and vascular endothelial cells, so that the new cells are used for substituting thescalded cells, the synthesis of elastic fibers and collagen can be facilitated, the activity of the scald surface tissues is restored, a vascular endothelial growth factor can adjust the generation of blood vessels, the renewing of the blood vessels can be facilitated, and the restoration renewing performance for the scald is relatively good. By adopting the scald restoration medicine, the problem that the existing scald medicine is slow in alleviating the pain, long in liquefying period and longer in wound healing time, the scars of different degrees can be left after the patient is healed,and the activity of the cell is damaged can be solved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine for repairing scalds. Background technique [0002] The scald medicine is one of the products in the technical field of medicine. Burns, also known as water burns, are common injuries. No matter when and where men, women and children can happen. Clinically, it is generally divided into three categories: "water scald, oil scald, burn (fire scald)". The nature of the disease is related to the size and depth of water, oil, fire and burns. Generally, the water scald is lighter, the oil scald is heavier, and the fire is more serious. If the scald area is too large, too deep, or the head, face, and chest are seriously injured, if it is not treated in time and treated properly, it can often be life-threatening. Local flushing and pain, followed by blisters, and even redness and swelling with broken skin and flesh. Or the scorched skin and meat rolls, the p...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K9/127A61K9/70A61K47/36A61K47/42A61P17/02A61K31/12A61K31/192A61K31/485A61K31/4965A61K31/58A61K35/35
CPCA61K9/127A61K9/7015A61K31/12A61K31/192A61K31/485A61K31/4965A61K31/58A61K35/35A61K36/23A61K47/36A61K47/42A61P17/02A61K2300/00
Inventor 雷国平庄文琴丁正颖
Owner CHANGZHOU AMANTE CHEM CO LTD
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