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Application of traditional Chinese medicine in the preparation of pharmaceutical preparations for treatment of myasthenia gravis complicated with thymoma

A technology for myasthenia gravis and pharmaceutical preparations, which is applied in drug combinations, antineoplastic drugs, and pharmaceutical formulations. It can solve the problems of short action time, easy repetition, and crisis-induced crises, and achieves small toxic and side effects, good curative effect, and low price. Effect

Active Publication Date: 2018-09-14
乞国艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Modern medicine often uses anticholinesterase drugs to improve symptoms. The drug has a short action time and is only a symptom control drug; clinically, hormone drugs and immunosuppressants are often used. It is easy to relapse after taking medicine; plasma exchange, immunoglobulin pulse therapy, and high-dose hormone pulse therapy have clear short-term curative effect, but the maintenance effect time is short, and it may induce crisis, which has certain risks, and is only suitable for adjuvant in the rescue of critically ill patients Treatment: Thymectomy or radiotherapy is currently recommended and more effective in clinical practice, especially for patients with thymoma or thymic hyperplasia, but the symptoms cannot be completely improved after surgery, and further medication is still required. For those who have been rescued in crisis, the chances of exacerbation and reoccurrence of crisis in clinical follow-up are significantly increased
At present, there is no effective drug to completely cure the disease. Because of its complex etiology, long course of disease, and easy recurrence, it has caused great economic and psychological burdens on patients, families and society.

Method used

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  • Application of traditional Chinese medicine in the preparation of pharmaceutical preparations for treatment of myasthenia gravis complicated with thymoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 Chinese medicine composition

[0046] 1. Accurately weigh the following Chinese medicine raw materials: 10 parts of astragalus, 10 parts of Codonopsis, 10 parts of Atractylodes macrocephala, 5 parts of Bupleurum, 5 parts of Cimicifuga, 5 parts of angelica, 3 parts of licorice, 3 parts of tangerine peel, 5 parts of wolfberry, and 12 parts of Cistanche , 10 parts of Arrowhead Mushroom, 10 parts of Scrophulariaceae, 12 parts of Fritillaria, and 12 parts of Scutellaria barbata.

[0047] 2. The above raw materials were crushed into coarse powder, 70% ethanol with 8 times the volume was added to reflux twice, each time for 1 hour, and the extracts were combined; concentrated under reduced pressure, and the ethanol was recovered to obtain the traditional Chinese medicine composition.

Embodiment 2

[0048] The preparation of embodiment 2 Chinese medicine composition

[0049]1. Accurately weigh the following Chinese medicine raw materials: 100 parts of astragalus, 30 parts of Codonopsis pilosula, 24 parts of Atractylodes macrocephala, 10 parts of Bupleuri, 10 parts of Cimicifuga, 10 parts of angelica, 6 parts of licorice, 6 parts of tangerine peel, 10 parts of wolfberry, and 12 parts of cistanche , 10 parts of Arrowhead Mushroom, 10 parts of Scrophulariaceae, 12 parts of Fritillaria, and 12 parts of Scutellaria barbata.

[0050] 2. Grind the above raw materials into coarse powder, add 70% ethanol of 10 times the volume to reflux twice, each time for 1 hour, and combine the extracts; concentrate under reduced pressure, recover ethanol, and obtain the traditional Chinese medicine composition.

Embodiment 3

[0051] The preparation of embodiment 3 Chinese medicine composition

[0052] 1. Accurately weigh the following Chinese medicine raw materials: 50 parts of astragalus, 20 parts of Codonopsis, 15 parts of Atractylodes macrocephala, 8 parts of Bupleurum, 8 parts of Cimicifuga, 8 parts of angelica, 4 parts of licorice, 5 parts of tangerine peel, 8 parts of medlar, and 12 parts of Cistanche , 12 parts of Arrowhead Mushroom, 10 parts of Scrophulariaceae, 12 parts of Fritillaria, and 12 parts of Scutellaria barbata.

[0053] 2. The above raw materials were crushed into coarse powder, refluxed twice with 70% ethanol of 9 times the volume, each time for 1 hour, and the extracts were combined; concentrated under reduced pressure, and the ethanol was recovered to obtain the traditional Chinese medicine composition.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating myasthenia gravis complicated with thymoma. The composition is prepared from the root of astragalus mongholicus, the root of codonopsis pilosula, the rhizome of atractylodes macrocephala, the dried root of bupleurum falcatum, the rhizome of cimicifugae foetidae, the dried root of Chinese angelica, the dried rhizome ofliquorice, dried tangerine peel, the fruit and root bark of lycium chinensis, the stem of herba cistanche, the dried pseudobulb cremastra appendiculata, the root of scrophularia ningpoensis, the driedbulb of fritillaria thunbergii and sculellaria barbata. The composition has reasonable compatibility, no toxic and side effects, has convenient processing and low cost, and has obvious effects in treating myasthenia gravis complicated with thymoma.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine treatment and relates to the application of traditional Chinese medicines, in particular to the application of traditional Chinese medicines in the preparation of pharmaceutical preparations for treating myasthenia gravis combined with thymoma. Background technique [0002] Myasthenia gravis is an autoimmune disease that mainly involves acetylcholine receptors on the post-synaptic membrane at the nerve-muscle junction, is mainly mediated by acetylcholine receptor antibodies, is dependent on cellular immunity, and involves complement. It is characterized by the abnormal fatigue of striated muscles, and the symptoms are light in the morning and heavy in the evening. Patients suffering from this disease have an insidious onset, fluctuating throughout the course of the disease, alternating remissions and relapses, mild cases of drooping eyelids, diplopia or strabismus, and inability to move...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P21/04A61P35/00
CPCA61K36/232A61K36/233A61K36/284A61K36/344A61K36/481A61K36/484A61K36/539A61K36/64A61K36/71A61K36/752A61K36/808A61K36/815A61K36/8966A61K36/898A61K2236/333A61P21/04A61P35/00A61K2300/00
Inventor 乞国艳
Owner 乞国艳