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Antiviral agent and antiviral food

An antiviral agent, virus technology, applied in antiviral agents, medical preparations containing active ingredients, food science, etc.

Active Publication Date: 2018-10-23
EUGLENA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although some vaccines against norovirus have been observed to be effective, they are still under development. It is expected to develop a norovirus vaccine or develop a norovirus therapeutic agent with a new mechanism

Method used

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  • Antiviral agent and antiviral food
  • Antiviral agent and antiviral food
  • Antiviral agent and antiviral food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] As the substance derived from euglena, euglena finesse powder (manufactured by Uluna Co., Ltd.) was used. 100 mg of the euglena finesse powder was dissolved in 1 ml of ethanol, and filtered through a 0.45 μm sterilizing filter to prepare an euglena solution (100 mg / ml). Use this solution as an antiviral agent.

Embodiment 2

[0158] A hot water extract of Euglena, which is a substance derived from Euglena, was prepared by the following procedure.

[0159] Euglena micronella powder (manufactured by Uluna Co., Ltd.) was subjected to extraction treatment with hot water under normal pressure, and then filtered under reduced pressure to separate the residue to obtain a hot water extract.

[0160] The prepared hot water extract was filtered through a 0.45 μm sterilizing filter to obtain a hot water extract (stock solution) of Euglena. This extract is used as an antiviral agent.

Embodiment 3

[0162] Paramylon, which is a substance derived from euglena, was prepared by the following procedure.

[0163] Euglena minutis powder (manufactured by Uluna Co., Ltd.) was added to distilled water, and stirred at room temperature for 2 days. The cell membrane was destroyed by ultrasonic treatment, and crude paramylon particles were recovered by centrifugation. Disperse the recovered paramylon particles in 1% sodium lauryl sulfate aqueous solution, treat at 95°C for 2 hours, and disperse the recovered paramylon particles by centrifugation again in 0.1% sodium lauryl sulfate aqueous solution and at 50°C for 30 minutes. Lipids and proteins were removed by this operation, followed by washing with acetone and ether, and drying at 50° C. to obtain purified paramylon particles.

[0164] 100 mg of the prepared paramylon powder was dissolved in 1 ml of dimethyl sulfoxide (DMSO), and filtered through a 0.45 μm sterilizing filter to obtain a paramylon solution (100 mg / ml). Use this so...

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Abstract

Provided are an antiviral agent and an antiviral food as novel methods for utilizing a euglena-derived substance. The antiviral agent and antiviral food, both comprising a euglena-derived substance asan active ingredient, are to be used for preventing or treating an infectious disease caused by an envelope-free RNA virus. Examples of the envelope-free RNA virus include rotaviruses belonging to Reoviridae. Examples of the euglena-derived substance include euglena, a hot water extract of euglena, paramylon and an alkali-treated paramylon.

Description

technical field [0001] The present invention relates to a novel antiviral agent and an antiviral food, and particularly to an antiviral agent and an antiviral food that contain a substance derived from euglena as an active ingredient and are used for the prevention or treatment of viral infections. Background technique [0002] Viral infection is an infectious disease caused by pathogenic viruses existing in the environment (air, water, soil, animals, etc.) The movement of (especially people) spreads the infection on a worldwide scale and becomes a public health problem. [0003] Viruses are generally microscopic parasites with a size of about 0.02 to 0.3 μm, and are mainly composed of a protein shell (capsid) and nucleic acid (RNA or DNA) inside the shell. [0004] For the virus, its replication is completely dependent on the cell, and it first adsorbs on the host cell and invades the cell. Thereafter, DNA and RNA are released (uncoated) in the cell and replicated, and sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/68A23L33/10A61K31/716A61P1/04A61P31/14
CPCA23L33/10C12N1/12C12P19/04A61K35/68A61P31/14A61P1/04A61K31/716A23L33/127
Inventor 中岛绫香铃木健吾伊势川裕二
Owner EUGLENA