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Preparation method and application of easily-degradable operating gauze with biocompatibility

A biocompatible and easily degradable technology, applied in spinning solution preparation, fabric, wet spinning, etc., can solve the problems of difficult healing, secondary injury of the wounded, and easy breeding of bacteria in gauze, so as to achieve improved performance, The effect of high biocompatibility and good application prospects

Inactive Publication Date: 2018-11-23
吴江康欣医用敷料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The structure of traditional gauze is very simple, and its function is also very limited. Because the tissue or blood of the wound or affected area stains the gauze, the gauze is easy to breed bacteria, and the gauze with bacteria is easy to cause wound infection and difficult to heal, causing secondary damage to the injured

Method used

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  • Preparation method and application of easily-degradable operating gauze with biocompatibility
  • Preparation method and application of easily-degradable operating gauze with biocompatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Mix polylactic acid, itaconic acid, hydroxyethyl cellulose powder and deionized water according to the mass ratio of 2:1:5:23, after ultrasonic dispersion treatment, fully stir to form a mixed spinning solution, ultrasonic The frequency of dispersion is 20kHz, the ultrasonic power is 200W, and the ultrasonic treatment time is 30 minutes, then the mixed spinning solution is centrifuged and left to stand overnight, and the precipitate in the mixed spinning solution is removed by filtration, and set aside;

[0023] (2) Carry out vacuum defoaming of the spinning solution, the vacuum degree of vacuum defoaming is -0.08MPa, and the defoaming time is 40 minutes, then add it to the wet spinning machine, measure it through the metering pump, and press it out from the spinneret Precipitate and form fiber filaments in coagulation bath, described coagulation bath is the mixed alcohol solution of dimethylacetamide, sodium sulfate, wherein the mol ratio of dimethylacetamide, sodiu...

Embodiment 2

[0029] (1) Mix polylactic acid, itaconic acid, hydroxyethyl cellulose powder and deionized water according to the mass ratio of 2:1:5:23, after ultrasonic dispersion treatment, fully stir to form a mixed spinning solution, ultrasonic The frequency of dispersion is 22.5kHz, the ultrasonic power is 250W, and the ultrasonic treatment time is 35 minutes, then the mixed spinning solution is centrifuged and left to stand overnight, and the precipitate in the mixed spinning solution is removed by filtration, and set aside;

[0030] (2) Carry out vacuum defoaming of the spinning solution, the vacuum degree of vacuum defoaming is -0.09MPa, and the defoaming time is 50 minutes, then add it to the wet spinning machine, measure it through the metering pump, and press it out from the spinneret Precipitate and form fiber filaments in coagulation bath, described coagulation bath is the mixed alcohol solution of dimethylacetamide, sodium sulfate, wherein the mol ratio of dimethylacetamide, sod...

Embodiment 3

[0036] (1) Mix polylactic acid, itaconic acid, hydroxyethyl cellulose powder and deionized water according to the mass ratio of 2:1:5:23, after ultrasonic dispersion treatment, fully stir to form a mixed spinning solution, ultrasonic The frequency of dispersion is 25kHz, the ultrasonic power is 300W, and the ultrasonic treatment time is 40 minutes, then the mixed spinning solution is centrifuged and left to stand overnight, and the precipitate in the mixed spinning solution is removed by filtration, and set aside;

[0037](2) Carry out vacuum defoaming of the spinning solution, the vacuum degree of vacuum defoaming is -0.1MPa, and the defoaming time is 60 minutes, then add it to the wet spinning machine, measure it through the metering pump, and press it out from the spinneret Precipitate and form fiber filaments in coagulation bath, described coagulation bath is the mixed alcohol solution of dimethylacetamide, sodium sulfate, wherein the mol ratio of dimethylacetamide, sodium ...

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Abstract

The invention discloses a preparation method and application of easily-biodegradable operating gauze with biocompatibility. According to the method, polylactic acid, itaconic acid, hydroxyethyl cellulose powder and deionized water are prepared into a blend spinning solution, then centrifuging and standing are carried out, precipitates are removed, then vacuum defoaming is carried out, then the spinning solution is added into a wet-process spinning machine, is metered by a metering pump, is pressed out by a spinning nozzle and then is separated out in a coagulating bath so as to form fiber filaments, the fiber filaments are subjected to stretching, shaping and spinning treatment so as to obtain grey cloth, then the obtained grey cloth is immersed in a hot water tank of a desizing, scouringand bleaching combined machine for high-temperature cleaning and modification, finally, the modified grey cloth is soaked into a mixed solution composed of sodium styrene sulfonate, magnesium chloridehexahydrate, chitosan and water for secondary modification, and scutching and drying are carried out so as to obtain a finished product of the gauze. The prepared operating gauze has extremely high biocompatibility, is safe and easily degradable and has a good application prospect in the industry of medical supplies.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a preparation method and application of biocompatible and easily degradable surgical gauze. Background technique [0002] Medical gauze is an indispensable medical product in surgery and surgical operations in medical institutions. Its main material is made of absorbent cotton. One of the main uses of medical gauze is to bandage patients' wounds. The structure of traditional gauze is very simple, and its function is also very limited. Because the tissue or blood of the wound or affected area stains the gauze, the gauze is easy to breed bacteria, and the gauze with bacteria is easy to cause wound infection and difficult to heal, causing secondary damage to the injured . This research is dedicated to the study of biocompatible surgical gauze, hoping to minimize the irritation to the surgical wound surface, and at the same time optimize the gauze production process and ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/256D06M11/155D06M15/03D01F8/02D01F8/14D01F1/10D01D1/02D01D1/10D01D5/06D03D15/00D06B3/10D06B15/00A61L15/62A61L15/18A61L15/20A61L15/28A61L15/26D06M101/06D06M101/32D03D15/283D03D15/50
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/62D01D1/02D01D1/10D01D5/06D01F1/10D01F8/02D01F8/14D03D15/00D06B3/10D06B15/00D06M11/155D06M13/256D06M15/03D06M2101/32D06M2101/06C08L5/08
Inventor 张志荣
Owner 吴江康欣医用敷料有限公司