Lipid compositions and uses thereof
A technology of lipid composition and composition, applied in drug combination, drug delivery, food science, etc., can solve problems such as undetermined causes
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[0315] In this specification and in the non-limiting examples provided below, reference is made to fat bases and fat blends. It should be understood that the terms "fat matrix" or "fat concentrate" or "fat matrix concentrate" are used to denote an enzymatically prepared lipid composition comprising triglycerides of vegetable origin with high sn- 2 Blends of palmitic acid; whereas the term "fat blend" is used to denote a lipid composition comprising a mixture of a fat base and an edible vegetable oil.
[0316] As shown below, a fat blend is a fat matrix comprising primarily triglycerides with high total palmitic acid and high sn-2 palmitic acid mixed with other edible vegetable oils. The edible vegetable oil may be natural vegetable oil, randomized vegetable oil, interesterified vegetable oil, enzymatically interesterified vegetable oil, at least two co-randomized vegetable oils, at least two co-esterified vegetable oils. Typically, this fat blend is used as the fat fraction i...
Embodiment 1
[0319] Example 1 - Preparation of Fat Bases and Fat Blends
[0320] Table 1 details the content of several fatty substrates enriched in high palmitic acid at the sn-2 position. The fatty matrix contains a high percentage of palmitic acid C16:0 at the sn-2 position of the triacylglycerol (TAG) and a high percentage of unsaturated fatty acids at the sn-1 and sn-3 positions.
[0321] The fatty matrix was prepared as described in publication WO 2005 / 036987 [3], which is fully incorporated herein by reference. In general, a triglyceride mixture rich in palmitic acid (preferably above 78%) is combined with a mixture of triglycerides rich in oleic acid (preferably above 75%) with low levels of palmitic and stearic acids (preferably below 6%) ) in a mixture of free fatty acids (FFA).
[0322] Briefly, triglyceride mixtures can be prepared from double fractionated palm stearin and FFA mixtures obtained after fractionation from palm kernel oil or from high oleic sunflower oil. The tw...
Embodiment 2
[0360] Example 2 - Effect of palmitic acid on catch-up growth in young rats
[0361] The purpose of this study was to examine whether the lipid composition of the invention affects the growth process, and especially the efficiency of the catch-up (CU) growth process. An animal model of catch-up growth using food restriction followed by ad libitum feeding.
[0362] Experimental setup:
[0363] Experiments were performed on prepubertal 23-day-old male Sprague-Dawley rats (Harlan Laboratories Ltd., Jerusalem, Israel) with an average body weight of 50 g. All animals were maintained under the same experimental conditions: mean ambient temperature 22°C±1°C, mean relative humidity 50%±2%, 12-hour light / dark cycle; lights turned off at 18:00 hours. All animals had free access to water and were all fed the same commercial rat chow (Teklad Rodent Diet (2018SC), 3.4 kcal / g; Teklad, South Easton, MA, USA) during food restriction periods. Rats were kept separately in individual cages. ...
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