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A kind of external transdermal absorption preparation for arthritis

A technology for transdermal absorption preparations and arthritis, which is applied in the field of external transdermal absorption preparations for arthritis, which can solve the problems of poor oral effect and difficult to achieve therapeutic effect, and achieve the effect of overcoming poor oral effect

Active Publication Date: 2021-08-31
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And because Rubescensine A is almost insoluble in water, the oral effect is poor, and it is difficult to achieve therapeutic effect

Method used

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  • A kind of external transdermal absorption preparation for arthritis
  • A kind of external transdermal absorption preparation for arthritis
  • A kind of external transdermal absorption preparation for arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1, the preparation of carrageenan (1%)

[0038] Take a small mortar that has been sterilized by high pressure, pour the weighed carrageenan into the small mortar, first grind it with a small amount of sterile 0.9% normal saline, and then slowly add the remaining normal saline in small amounts for several times . Note: Prepare 24 hours before the experiment, and place it overnight in a 4-degree refrigerator. Use while grinding.

[0039] 2. Preparation of Oridonin A for external transdermal absorption (1% ointment)

[0040] Raw materials: Oridonin 10mg, liquid paraffin 800mg, petrolatum 90mg, propylene glycol 100mg.

[0041] Method: Take Rubescensin A in a mortar, add a small amount of liquid paraffin to grind, grind a small amount several times to a uniform and fine paste, then gradually add Vaseline and propylene glycol to the full amount, and grind until uniform.

[0042] 3. The effect of oridonin A external transdermal absorption preparation on carrageenan-induced...

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PUM

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Abstract

The invention discloses an external transdermal absorption preparation for arthritis, which contains oridonin, its pharmaceutically acceptable derivative or its prodrug. Utilize transdermal absorption technology in the present invention, consider factors such as the concentration of Rubescensin A comprehensively, the selection of matrix, the selection of transdermal absorption enhancer, make Rubescensin A enter the body through the skin, and can directly reach joints place, to overcome the defects of poor oral effect of oridonin, verified by experiments, the external transdermal absorption preparation of oridonin in the present invention has a direct and significant inhibitory effect on acute arthritis induced by carrageenan The action characteristics indicate that it can be used as an external drug dosage form for arthritis to treat arthritis and other related diseases.

Description

technical field [0001] The invention relates to an external transdermal absorption preparation for arthritis, in particular to an external transdermal absorption preparation for arthritis containing oridonin, its pharmaceutically acceptable derivative or its prodrug. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease characterized by continuous synovial hyperplasia, cartilage and bone destruction, and chronic inflammation, multiple joint swelling, pain and the resulting Joint stiffness and even loss of function are clinical manifestations, and its etiology and pathogenesis are still unclear. [0003] Osteoarthritis affects more than 3.8 percent of people, while rheumatoid arthritis affects about 0.24 percent. Overall, the disease becomes more prevalent with age. Therefore, it is particularly urgent to continue to study anti-osteoarthritis drugs. [0004] Rabdosiarubescens (Hemsl.) Hara is a plant of the genus Lamiaceae, which is widely distrib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/352A61K47/10A61P19/02
CPCA61K9/0014A61K9/06A61K31/352A61K47/10A61P19/02
Inventor 李晓娟邹斌华谭艳辉
Owner SOUTHERN MEDICAL UNIVERSITY