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A detection method and its application for the analysis of anti-infective drugs commonly used in adults based on SNP sites

An anti-infective drug and analysis method technology, applied in the field of adult anti-infective drug medication analysis system, can solve the problems of high cost and low detection efficiency, etc.

Active Publication Date: 2021-08-20
深圳一道医学检验实验室
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Problems solved by technology

[0009] At present, the research on the polymorphism of these gene loci is mainly based on the Sanger sequencing method, which can only detect a certain region of a certain sample, and the detection efficiency is low and the cost is high

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  • A detection method and its application for the analysis of anti-infective drugs commonly used in adults based on SNP sites
  • A detection method and its application for the analysis of anti-infective drugs commonly used in adults based on SNP sites
  • A detection method and its application for the analysis of anti-infective drugs commonly used in adults based on SNP sites

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Embodiment Construction

[0034] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0035] In order to better understand the present invention, definitions and explanations of relevant terms are provided below.

[0036] The term "high resolution melting curve method" as used herein mainly refers to the difference based on the physical properties of nucleic acid molecules. The fragment length, GC content, and GC distribution of different nucleic acid molecules are different, so any double-stranded DNA molecule will have its own shape and position of the melti...

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Abstract

The invention discloses a detection method for anti-infective drugs commonly used in adults based on SNP sites. The combination of SNP sites for the risk assessment of common anti-infective drugs in adults includes 67 SNP sites for detection of drug toxicity, drug metabolism and drug response. SNP site combinations and their specific primers. The sample DNA was amplified by PCR with site-specific primers, and the difference between the melting curve and the standard melting curve was analyzed, and the Tm value of the PCR amplification product was compared to obtain the corresponding genotyping results. This detection method can be applied to the rapid screening of the applicability of common anti-infective drugs in adults, and provides guidance for the reasonable selection of adult medications. The detection method has the advantages of simple operation, high efficiency, high specificity, and economic benefits.

Description

technical field [0001] The invention relates to the technical field of gene detection, in particular to a SNP-site-based analysis system for adult anti-infective drugs and its application. Background technique [0002] Drug gene detection is to extract the DNA in the patient's oral mucosa, interpret the genes related to the drug response, and predict the degree of adverse reactions of the patient to the specific drug according to the statistical results of the clinical response of different genotypes to the specific drug. to a certain guiding role. [0003] From 1999 to 2017, the national adverse drug reaction monitoring network received a total of 12.182 million copies of the "Adverse Drug Reaction / Event Report Form", and in 2017 a total of 1.43 million "Adverse Drug Reaction / Event Report Forms" were received. There were 126,000 reaction / incident reports, accounting for 8.8% of the total number of reports for the same period. Among the suspected drugs involved in adverse ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12Q1/6869C12N15/11
CPCC12Q1/6869C12Q1/6883C12Q2600/106C12Q2600/156C12Q2535/122
Inventor 欧阳秦毛燕潘明芳
Owner 深圳一道医学检验实验室
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