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Preparation method of fluorescent nano material

A technology of fluorescent nanomaterials and mesoporous templates, applied in the field of preparation of fluorescent nanomaterials, can solve the problems of low output, low quantum yield, high toxicity, etc., and achieve improved stability, good biocompatibility, and simple process Effect

Inactive Publication Date: 2019-01-04
BAOJI UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existence of quantum dots and organic dyes is generally more toxic to organisms, and the quantum yield is lower, the post-processing technology is more complicated, and the output is less

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The embodiment of the present invention provides a method for preparing fluorescent nanomaterials, including the following steps:

[0019] S1, after mixing 0.5mmol / L 6-diamidino-2-phenylindole solution and 0.1mmol / L bovine serum albumin solution in a mass ratio of 2:1, mechanically stirred for 24 hours to obtain a solution A;

[0020] S2. Ultrasonically dissolve the mesoporous template agent hexadecyltrimethylammonium bromide in an aqueous solution of ethanol, add ammonia water, stir magnetically for one hour, then add tetraethylorthosilicate dropwise at a rate of 1ml / min to form Mesoporous silica containing a mesoporous template; the amount of the mesoporous template cetyltrimethylammonium bromide is between 0.8g and 1.2g, and the ratio of ethanol: deionized water is 180ml / 300ml ; The amount of ammonia water is 4ml ~ 10ml;

[0021] Dissolving the product obtained above in deionized water and etching at high temperature to obtain hollow mesoporous silica containing a ...

Embodiment 2

[0025] The embodiment of the present invention provides a method for preparing fluorescent nanomaterials, including the following steps:

[0026] S1, after mixing 0.5mmol / L 6-diamidino-2-phenylindole solution and 0.1mmol / L bovine serum albumin solution in a mass ratio of 5:1, mechanically stirred for 24 hours to obtain a solution A;

[0027] S2. Ultrasonically dissolve the mesoporous template agent hexadecyltrimethylammonium bromide in an aqueous solution of ethanol, add ammonia water, stir magnetically for one hour, then add tetraethylorthosilicate dropwise at a rate of 1ml / min to form Mesoporous silica containing a mesoporous template; the amount of the mesoporous template cetyltrimethylammonium bromide is between 0.8g and 1.2g, and the ratio of ethanol: deionized water is 180ml / 300ml ; The amount of ammonia water is 4ml ~ 10ml;

[0028] Dissolving the product obtained above in deionized water and etching at high temperature to obtain hollow mesoporous silica containing a ...

Embodiment 3

[0032] The embodiment of the present invention provides a method for preparing fluorescent nanomaterials, including the following steps:

[0033] S1, after mixing 0.5mmol / L 6-diamidino-2-phenylindole solution and 0.1mmol / L bovine serum albumin solution in a mass ratio of 3:1, mechanically stirred for 24 hours to obtain a solution A;

[0034] S2. Ultrasonically dissolve the mesoporous template agent hexadecyltrimethylammonium bromide in an aqueous solution of ethanol, add ammonia water, stir magnetically for one hour, then add tetraethylorthosilicate dropwise at a rate of 1ml / min to form Mesoporous silica containing a mesoporous template; the amount of the mesoporous template cetyltrimethylammonium bromide is between 0.8g and 1.2g, and the ratio of ethanol: deionized water is 180ml / 300ml ; The amount of ammonia water is 4ml ~ 10ml;

[0035] Dissolving the product obtained above in deionized water and etching at high temperature to obtain hollow mesoporous silica containing a ...

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Abstract

The invention discloses a preparation method of a fluorescent nano material. The preparation method comprises the following steps: S1, mixing a 0.5 mmol / L 6-diamidino-2-phenylindole solution with a 0.1 mmol / L bovine serum albumin solution according to a mass ratio of (2-5):1, and mechanically stirring for 24 hours to obtain a solution A; S2, preparing hollow mesoporous silica; and S3, adding a suitable amount of mesoporous silica nanospheres into the solution A according to the mass ratio of (0.5-2):1, magnetically stirring for 24 hours, centrifuging, reacting in an oven at a constant temperature of 160 DEG C for 7 days, taking out, washing for 3 times with water and ethanol respectively, and spray-drying to obtain the fluorescent nano material. The synthesis process provided by the invention is simple, the obtained material is high in biocompatibility, and the fluorescent component can adhere to the inner and outer surfaces of the mesoporous silica nanospheres, thereby improving the stability of the fluorescent component.

Description

technical field [0001] The invention relates to the technical field of luminescent materials, in particular to a method for preparing fluorescent nanometer materials. Background technique [0002] Fluorescent nanomaterials have good application prospects in the fields of optoelectronic device assembly, cell imaging, drug delivery, biosensing, and disease diagnosis. Not only that, in the fields of biological science and clinical medicine, fluorescent labeling has become a very important technical means. Existing fluorescent labeling materials usually include noble metal nanoclusters, quantum dots, composite fluorescent nanoparticles, and organic dyes. The presence of quantum dots and organic dyes is generally more toxic to organisms, and the quantum yield is lower, the post-processing technology is more complicated, and the output is less. Contents of the invention [0003] In order to solve the above problems, the present invention provides a method for preparing fluores...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/06C09K11/59B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C09K11/02C09K11/06C09K11/59C09K2211/1007C09K2211/1029
Inventor 李慧勤窦树梅赵微微孟丽青邓翠安百江
Owner BAOJI UNIV OF ARTS & SCI