Dicranostigma leptopodum pharmaceutical preparation and preparation method thereof

A technology of drug preparation and reincarnation, which is applied in the direction of drug combination, pharmaceutical formula, pill delivery, etc., can solve the problems of low active ingredient content and low drug loading capacity, and achieve the increase of protocatechuic acid content and drug loading capacity , Conducive to the effect of preparation molding and clinical medication

Inactive Publication Date: 2019-01-08
朗致集团万荣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, due to the low content of active ingredients in the Lema-back preparation prepared by the existing method, the drug loading per tablet is not high. How to increase the conten

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0042] Example 1

[0043] This embodiment prepares Lemahui tablets through the following steps

[0044] Decoct 3kg of the whole grass in 90℃ water for 2 times, add 6 times the amount of water for the first time and cook for 1 hour, add 4 times the amount of water for the second time, and cook for 0.5 hours. Combine the two decocted The decoction liquid is filtered and concentrated to obtain a concentrated liquid (relative density of 1.23). Add ethanol to the concentrated liquid to make the alcohol content reach 70%, add alcohol while stirring, let stand for 24 hours, filter the resulting precipitate, and concentrate the filtrate to a relative density of 1.35 , Add 0.4g magnesium stearate and 110g dextrin, mix well, granulate with an 18-mesh sieve, dry, granulate, and compress 1000 tablets, each weighing 0.22g. Each tablet contains 3g of drug.

Example Embodiment

[0045] Example 2

[0046] This embodiment prepares Lema drop pills by the following steps

[0047] Decoct 3kg of the whole grass in 85℃ water for two times, add 6 times the amount of water for the first time and cook for 1.5 hours, add 4 times the amount of water for the second time and cook for 1 hour, combine the two decocted The decoction liquid is filtered and concentrated to obtain a concentrated liquid (relative density of 1.23). Add ethanol to the concentrated liquid to make the alcohol content reach 70%, and let it stand for 18 hours. The precipitate is filtered to obtain the filtrate, which is concentrated to a relative density of 1.30 and dried to obtain Lemahui extract, and then mixed with PEG2000 3 times the quality of Lemahui extract, placed in a heating container to heat to form a molten state, using the temperature difference between the dropping pill machine and the coolant to shrink the molten molten liquid into a shape The dropping pills were prepared, and 10,000...

Example Embodiment

[0048] Example 3

[0049] This embodiment prepares Lemahui tablets through the following steps

[0050] Decoct 3kg of the whole grass in 80℃ water for two times, add 5.5 times the amount of water for the first time and cook for 1 hour, add 4 times the amount of water for the second time, and cook for 0.5 hours. Combine the two decocted The decoction liquid is filtered and concentrated to obtain a concentrated liquid (relative density of 1.20). Add ethanol to the concentrated liquid to make the alcohol content reach 70%, and let it stand for 18 hours. The precipitate is filtered to obtain the filtrate, which is concentrated to a relative density of 1.40 and dried to obtain Lemahui extract, then pulverize the Lemahui extract, pass a 100-mesh sieve, add an appropriate amount of 85% alcohol to make a soft material, use a 20-mesh sieve to make granules, ventilate and dry at 60℃, add magnesium stearate 0.35g, 0.05g silicon dioxide, 330g dextrin, granulated with an 18-mesh sieve, dried, ...

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Abstract

The invention provides a dicranostigma leptopodum pharmaceutical preparation and a preparation method thereof. The preparation method comprises the following steps: (A) adding water into dicranostigmaleptopodum herb to be cooked, filtering the solution, and concentrating the filtrate to obtain a dicranostigma leptopodum concentrated solution; (B) adding ethanol into the dicranostigma leptopodum concentrated solution in the (A) for alcohol precipitation, leaving the solution to stand, and filtering the solution to obtain a filtrate; and (C) concentrating the filtrate in the (B) and adding pharmaceutically acceptable auxiliary materials, and preparing the dicranostigma leptopodum pharmaceutical preparation by means of a known preparation method of the preparation. According to the pharmaceutical preparation and the preparation method thereof, the dicranostigma leptopodum herb is directly cooked and alcohol-precipitated to prepare extract which is further processed into various preparations. Compared with an existing process of the dicranostigma leptopodum preparation, the step of adding dicranostigma leptopodum herb powder is saved and the step of alcohol precipitation to remove impurities is canceled, so that the protocatechuic acid content in the preparation is improved greatly, and the drug loading capacity is improved by 1.5-4 times. The preparation formation and clinical medication are further facilitated.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a lemahui pharmaceutical preparation and a preparation method thereof. Background technique [0002] The ingredient of Lemahui is Shuimanjing, which has the functions of clearing away heat and nourishing the lungs, relieving cough and reducing phlegm, diuresis and treating stranguria. It is used to treat diseases such as tuberculosis and hemoptysis, cough, phlegm and dyspnea, dysuria, hot stranguria and astringent pain. It is of great significance for the treatment of related diseases to prepare a suitable dosage form for reintroduction. [0003] CN100406003A discloses a Lemahui dripping pill, which is prepared from Lemahui as a raw material together with a pharmaceutically acceptable carrier as a matrix. (1) Take an appropriate amount of Lemahui in units of g or kg, and decoct it with water Three times, 2 hours for the first time, 1 hour for the second time, and 0.5 ho...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/20A61P11/00A61P31/06A61P7/04A61P11/14A61P11/06A61P13/00
CPCA61K9/2013A61K36/81A61K2236/331A61K2236/51A61K2236/53A61P7/04A61P11/00A61P11/06A61P11/14A61P13/00A61P31/06
Inventor 王锋杨满辉
Owner 朗致集团万荣药业有限公司
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