Preparation method of nanometer hydroxyapatite-chitosan artificial bone

A nano-hydroxyapatite and artificial bone technology, which is applied in pharmaceutical formulations, pharmaceutical sciences, prostheses, etc., can solve problems such as processing difficulties, limited popularization and application, and achieves simple preparation process, controllable process parameters, and good processing performance. Effect

Active Publication Date: 2019-01-08
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, due to the strong hydrogen bond associations in and between chitosan molecules, chitosan has a compact crystalline structure, does not melt, and is also insoluble in common organic solvents, resulting in processing difficulties and limiting its popularization and application.

Method used

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  • Preparation method of nanometer hydroxyapatite-chitosan artificial bone
  • Preparation method of nanometer hydroxyapatite-chitosan artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 nanometer hydroxyapatite-chitosan artificial bone

[0033] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 600, configure it into a 5% aqueous solution, and add nano-hydroxyapatite under stirring. After the addition, keep stirring at 55°C for 6 hours, then ultrasonically disperse for 3 hours, filter, and the filter cake is washed with absolute ethanol in turn. 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 100° C. for 24 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0034] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while h...

Embodiment 2

[0037] The preparation of embodiment 2 nanometer hydroxyapatite-chitosan artificial bone

[0038] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 800, configure it into a 5% aqueous solution, and add nano-hydroxyapatite under stirring. After the addition, keep stirring at 60°C for 6 hours, then ultrasonically disperse for 3.5 hours, filter, and the filter cake is washed with absolute ethanol in turn. 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 90° C. for 24 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0039] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while ...

Embodiment 3

[0042] The preparation of embodiment 3 nanometer hydroxyapatite-chitosan artificial bone

[0043] 1. Preparation of surface-modified nano-hydroxyapatite. Take polyethylene glycol 1000, configure it into a 10% aqueous solution, add nano-hydroxyapatite under stirring, after the addition, keep stirring at 80°C for 10 hours, then ultrasonically disperse for 3 hours, filter, and filter the cake in turn with absolute ethanol 1. After washing with chloroform, dry the organic solvent, vacuum-dry at 140° C. for 40 hours, and grind to obtain surface-modified nano-hydroxyapatite.

[0044] 2. Preparation of butyrylated chitosan. Take chitosan powder, add methanesulfonic acid in an ice-water bath, stir to make chitosan fully swell, slowly add butyric anhydride dropwise under continuous stirring, react at room temperature for 8 hours, overnight at -20°C, take out, filter, double steam Suspended in water, adjusted to pH 7 with ammonia water, boiled for 2 hours, filtered while hot, washed wit...

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Abstract

The invention discloses a preparation method of a nanometer hydroxyapatite-chitosan artificial bone. In particular, the artificial bone is prepared from surface modified nanometer hydroxyapatite and chitosan through mixing, extruding granulation and injection molding; and the surface of the nanometer hydroxyapatite is modified, the dispersibility of the nanometer hydroxyapatite is improved and thecombining capacity of the nanometer hydroxyapatite and the chitosan is improved, so that the finally obtained artificial bone has higher mechanical property and hydrophilcity.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of nano-hydroxyapatite-chitosan artificial bone. Background technique [0002] The research on biomedical materials is an emerging interdisciplinary subject developed in recent decades. With the development of global aging trend and frequent occurrence of bone trauma, bone repair and bone replacement materials have gradually become the focus of this field. With the gradual improvement of people's requirements for material performance, a single type of biomaterial is difficult to meet the clinical requirements. Therefore, the use of materials with different properties for composite biomaterials to obtain composite biomaterials with excellent clinical performance is a current research hotspot. [0003] With the continuous deepening of research, the research on nano-hydroxyapatite / chitosan composite materials has made great progress. Practice has proved that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/50
CPCA61L27/46A61L27/50A61L2400/12A61L2430/02C08L5/08
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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