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Application of diosgenin in the preparation of drugs for inhibiting vascular calcification

A technology of diosgenin and vascular calcification, which is applied in the field of medicine and can solve the problems that diosgenin has not been reported.

Pending Publication Date: 2019-01-11
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the results of diosgenin in the treatment of vascular calcification and the preparation and application of vascular calcification drugs have not been reported.

Method used

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  • Application of diosgenin in the preparation of drugs for inhibiting vascular calcification
  • Application of diosgenin in the preparation of drugs for inhibiting vascular calcification
  • Application of diosgenin in the preparation of drugs for inhibiting vascular calcification

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1 Animal model establishment

[0022] All animal care and experimental procedures are carried out in accordance with the requirements of the Animal Management and Use Committee (IACUC) of the Laboratory Animal Science Center of Dalian Medical University. Select 8-week-old SPF female LDLr - / - Mice conduct research. The environment of the animal room is set at a temperature of (22-25°C), and the white night cycle is 12 hours / 12 hours a day. The animals can freely draw water and food in the cage. The mice have a week to adapt to the new environment, and then continue as follows 12 weeks.

[0023] 2 Construction and intervention of vascular calcification model

[0024] The mice were randomly divided into five groups: the first group (n=6) only received normal diet and ordinary feed (blank group); the second group (n=6) normal diet and ordinary feed, diosgenin 35mg / kg daily gavage One time (Dioscin; Nanjing Jingzhu Biotechnology Co., Ltd.) (Dioscin is dissolved in 0.5% carboxyme...

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Abstract

The invention discloses the application of diosgenin in the preparation of drugs for inhibiting vascular calcification, in particular relates to the application of a natural steroid saponin compound--diosgenin, which has remarkable effect in inhibiting vascular calcification diseases. Specifically, diosgenin is used in the preparation of the following kinds of drugs, including alleviating and reversing vascular damage, A medicine for alleviate and reversing vascular atherosclerotic lesion, Alleviating and reversing decreased vascular compliance, increased stiffness, anti-inflammatory, anti-oxidant, anti-DNA damage, and anti-vascular smooth muscle cell apoptosis targeting the abdominal aorta, and use in the preparation of drugs that protect and maintain vascular homeostasis by downregulating the Rac1 / P66shc signaling pathway.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to the application of dioscin in the preparation of drugs for inhibiting vascular calcification. Background technique [0002] Vascular calcification is a disease that occurs in atherosclerotic blood vessels, which can lead to decreased vascular compliance and increased stiffness. It also exists in the pathological process of diabetes, chronic kidney disease, hypertension and other diseases. It causes cardiovascular and cerebrovascular diseases. An important factor in high mortality. Studies have shown that many factors are involved in the occurrence of vascular calcification. The key problem of vascular calcification is the phenotypic transformation of vascular smooth muscle cells under inducing conditions. Previous studies believe that vascular calcification is the passive deposition of calcium salts on the blood vessel wall. However, many studies in recent years have shown that vas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/10A61P9/14A61P29/00A61P39/06
CPCA61K31/7048A61P9/10A61P9/14A61P29/00A61P39/06
Inventor 孙慧君耿仲亮彭金咏王长远马晓东孟强刘琦刘志浩吴敬敬
Owner DALIAN MEDICAL UNIVERSITY