Application of a nitrophenyl ester sesquiterpene compound in the preparation of anti-inflammatory drugs
A technology of sesquiterpenoids and nitrophenyl esters, which can be used in anti-inflammatory agents, drug combinations, antipyretics, etc., and can solve the problems that biological activities have not been reported.
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Embodiment 1
[0023] An external transdermal absorption preparation of nitrophenyl sesquiterpenoid FY11, which contains 5 mg of nitrophenyl sesquiterpene FY11, an appropriate amount of petrolatum, an appropriate amount of liquid paraffin, and the structural formula of nitrophenyl sesquiterpene FY11 as follows:
[0024]
[0025] The preparation method is as follows: take the nitrophenyl sesquiterpene compound FY11 and put it in a mortar, add a small amount of liquid paraffin, grind it to a uniform and fine paste, then add vaseline step by step to the full amount, and grind until uniform.
Embodiment 2
[0027] Effects of nitrophenyl ester sesquiterpenoid FY11 transdermal preparation on carrageenan-induced acute arthritis
[0028] Take female C57BL / 6 mice about 8-10 weeks old, place them in a clean animal room in advance and adapt to the environment for a week, then divide the mice into blank group, model group, nitrophenyl ester sesquiterpenoid FY11 group and positive In the drug group, solvent ointment, 1% nitrophenyl ester sesquiterpene drug varnish, and positive control Voltaren emulsion were applied to the left and right hind limbs of the mice at the same time, once every 5 minutes, for 6 consecutive times. At 30 minutes after administration, 30 μl of 1% carrageenan was applied to the right hind paw s.c of each mouse to induce inflammation. After 5 hours, the mice were sacrificed, the thickness of the left and right toes of the mice was measured, and the mice's feet were cut symmetrically from the ankle joint, weighed, and the swelling degree of the mouse's feet was deter...
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