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Application of nitrophenyl ester sesquiterpenoid for preparing anti-inflammatory drug

A technology of sesquiterpenes and anti-inflammatory drugs, applied in the preparation of anti-inflammatory drugs, in the field of nitrophenyl sesquiterpenoids, can solve the problems that biological activity has not been reported

Active Publication Date: 2019-01-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Apart from this, other biological activities of FY8 have not been reported

Method used

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  • Application of nitrophenyl ester sesquiterpenoid for preparing anti-inflammatory drug
  • Application of nitrophenyl ester sesquiterpenoid for preparing anti-inflammatory drug
  • Application of nitrophenyl ester sesquiterpenoid for preparing anti-inflammatory drug

Examples

Experimental program
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Effect test

Embodiment 1

[0023] A nitrophenyl sesquiterpene compound FY8 transdermal absorption preparation, which contains nitrophenyl sesquiterpene compound FY85 mg, an appropriate amount of petrolatum, and an appropriate amount of liquid paraffin. The structural formula of the nitrophenyl sesquiterpene compound FY8 is as follows:

[0024]

[0025] Its preparation method is as follows: take nitrophenyl sesquiterpene compound FY8 and put it in a mortar, add a small amount of liquid paraffin, grind it to a uniform and fine paste, then gradually add vaseline to the full amount, and grind until uniform.

Embodiment 2

[0027] Effects of nitrophenyl ester sesquiterpenoid FY8 transdermal preparation on carrageenan-induced acute arthritis

[0028] Take female C57BL / 6 mice about 8 to 10 weeks old, place them in a clean animal room in advance and adapt to the environment for a week, then divide the mice into blank group, model group, nitrophenyl sesquiterpene compound FY8 group and positive Drug group, 6 mice in each group, then apply solvent ointment, 1% nitrophenyl ester sesquiterpene drug varnish, and positive control Voltaren emulsion on the left and right hind limbs of the mice at the same time, once every 5 minutes, continuously 6 times. At 30 minutes after administration, 30 μl of 1% carrageenan was applied to the right hind paw s.c of each mouse to induce inflammation. After 5 hours, the mice were sacrificed, the thickness of the left and right toes of the mice was measured, and the mice's feet were cut symmetrically from the ankle joint, weighed, and the swelling degree of the mouse's f...

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Abstract

The invention discloses an application of a nitrophenyl ester sesquiterpenoid FY8, a pharmaceutically acceptable derivative thereof or a prodrug thereof for preparing an anti-inflammatory drug. The condition that the nitrophenyl ester sesquiterpenoid FY8 has the direct remarkable inhibiting effect to inflammation is verified, especially arthrophlogosis, and can be used for preparing the anti-inflammatory drug, and treating diseases, such as the arthrophlogosis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of nitrophenyl sesquiterpene compound FY8 in the preparation of anti-inflammatory drugs. Background technique [0002] Anti-inflammatory drugs are the second largest class of drugs in clinical practice after anti-infective drugs. Anti-inflammatory drugs currently used clinically can be roughly divided into: non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs (NSAIDs) have antipyretic, analgesic, anti-inflammatory, and anti-rheumatic effects. Its pharmacological effects are mainly exerted by affecting the metabolites of arachidonic acid. With the increasing demand of NSAIDs, the side effects of digestive tract caused by them are becoming more and more prominent, especially in the gastrointestinal tract. Long-term use of traditional NSAIDs will inhibit the activity of COX-1 and reduce the synthesis of PGs that m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/92A61K31/365A61P29/00A61P19/02
CPCA61P19/02A61P29/00C07D307/92
Inventor 李晓娟谭艳辉邹斌华周雪峰
Owner SOUTHERN MEDICAL UNIVERSITY