Application of supramolecular framework materials based on eight-membered melon rings in drug controlled release
An eight-membered melon ring and frame material technology, which can be used in drug combinations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc.
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Embodiment 1
[0049] Example 1: The application of a supramolecular framework material based on eight-membered melon rings in drug controlled release is to dissolve the eight-membered melon rings in a hydrochloric acid solution with a concentration of 6mol / L, and dissolve 5g per liter of hydrochloric acid solution Eight-membered melon rings, left to stand for 7 days to obtain colorless crystals, after filtration, the crystals were dried in a vacuum oven, which was the supramolecular framework material of eight-membered melon rings; adefovir was dissolved in water to make a concentration of 1×10 -3 For the aqueous solution of M, add 1 g of the supramolecular framework material of eight-membered cucurbit rings to every 4 ml of aqueous solution, shake in a water bath at room temperature for 2 hours to load drug molecules, filter and dry, and obtain the supramolecular framework materials of eight-membered cucurbit rings loaded with adefovir.
Embodiment 2
[0050] Example 2: The application of a supramolecular framework material based on eight-membered melon rings in the controlled release of drugs is to dissolve the eight-membered melon rings in a hydrochloric acid solution with a concentration of 6mol / L, and dissolve 3g per liter of hydrochloric acid solution The eight-membered melon ring was left to stand for 5 days to obtain colorless crystals. After filtering, the crystal was dried in a vacuum oven to form the supramolecular framework material of the eight-membered melon ring; levofloxacin was dissolved in water to make a concentration of 1×10 -3 For the aqueous solution of M, add 0.5 g of the supramolecular framework material of eight-membered cucurbit rings to every 4 ml of aqueous solution, shake in a water bath at room temperature for 1 hour to load drug molecules, filter and dry to obtain the supramolecular framework materials of eight-membered cucurbit rings loaded with levofloxacin.
Embodiment 3
[0051] Example 3: The application of a supramolecular framework material based on eight-membered melon rings in the controlled release of drugs is to dissolve the eight-membered melon rings in hydrochloric acid solution with a concentration of 6mol / L, and dissolve 7g per liter of hydrochloric acid solution The eight-membered melon ring was left to stand for 10 days to obtain colorless crystals, and after filtration, the crystal was dried in a vacuum oven to become the supramolecular framework material of the eight-membered melon ring; the didanosin was dissolved in water to make a concentration of 1×10 -3 For the aqueous solution of M, add 1.5 g of supramolecular framework material of eight-membered melon ring to every 4 ml of aqueous solution, shake in a water bath at room temperature for 3 hours to load drug molecules, filter and dry to obtain supramolecular framework material of eight-membered melon ring loaded with didanosin .
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