Sodium alginate composition and application thereof

Abstract

The invention discloses a sodium alginate composition, which is prepared from the following components in parts by weight: 50-100 parts of sodium alginate, 1-10 parts of calcium salt, 1-10 parts of zinc salt and 2-5 parts of a crosslinking agent. The sodium alginate composition provided by the invention and a hemostatic material have the characteristics of being rapid in hemostasis, good in biocompatibility, biodegradable and absorbable, simple in treatment, free from debridement, low in price and the like, and are suitable for hemostasis of traumatic wounds.

Description

technical field [0001] The invention relates to a polymer compound and its application, in particular to a sodium alginate composition and its application. Background technique [0002] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum, and its molecules are composed of β-D-mannuronic acid (β-D-mannuronic, M) and α-L-gulo Uronic acid (α-L-guluronic, G) is formed by linking (1→4) bonds. The aqueous solution of sodium alginate has a high viscosity and has been used as a food thickener, stabilizer, emulsifier, etc. Sodium alginate is a non-toxic food, which was included in the United States Pharmacopoeia as early as 1938. Sodium alginate contains a large amount of -COO-, which can exhibit polyanion behavior in aqueous solution and has certain adhesion, and can be used as a drug carrier for treating mucosal tissues. Under acidic conditions, -COO- transforms into -COOH, the degree of ionization decreases, the hydrophilicity of...

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Problems solved by technology

[0003] At present, most domestic medical hemostatic materials are water-soluble hemostatic gauze, but gauze has no anti-inflammatory and antibacterial effects for hemostasis, and has defects such as slow hemostasis, long absorption time in the body, and easy to cause inflammatory reactions. Therefore, people turn their attention to hemostatic powder. However, due to the complex preparation, high price and unsatisfactory hemostatic effect of the existing hemostatic powder, it has not been applied as a mainstream hemostatic product.

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