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A kind of sustained-release potassium hydrogen persulfate preparation and preparation method thereof

A potassium hydrogen persulfate preparation and a potassium hydrogen persulfate technology are applied in the field of slow-release potassium hydrogen persulfate preparations and their preparation, and can solve the problem of uncontrollable release rate of potassium hydrogen persulfate, preparations susceptible to moisture and deterioration, treatment cost and treatment effect Insufficient and other problems, to achieve the effect of prolonging the effective response time, good processing effect, and simplifying the operation

Active Publication Date: 2022-07-01
ZHONGKAI UNIV OF AGRI & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to propose a slow-release type potassium persulfate preparation and preparation method thereof, to solve the uncontrollable release rate of potassium persulfate produced in the existing potassium persulfate preparation, poor treatment effect, The problems of cumbersome operation, easy moisture deterioration and high processing cost

Method used

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  • A kind of sustained-release potassium hydrogen persulfate preparation and preparation method thereof
  • A kind of sustained-release potassium hydrogen persulfate preparation and preparation method thereof
  • A kind of sustained-release potassium hydrogen persulfate preparation and preparation method thereof

Examples

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Embodiment 1

[0049] (1) Composition and ratio of sustained-release potassium hydrogen persulfate preparation: The mass ratio of each raw material component of drug-loaded pill core 1 is: potassium hydrogen persulfate 0.5: starch 15: sucrose 4: sodium carboxymethyl cellulose 0.05: Water 5; the mass ratio of each raw material component of inner film coat 2 is: ethyl cellulose 15: triethyl citrate 3: polyethylene glycol-2000 4: dehydrated alcohol 80; each raw material of outer film coat 3 The mass ratio of the components is: hydroxypropyl methylcellulose 5: polyethylene glycol-400 5: potassium hydrogen persulfate 2: water 100.

[0050] (2) Preparation of sustained-release potassium hydrogen persulfate preparation:

[0051] ①Make drug-loaded pill core 1: Dissolve sucrose and sodium carboxymethyl cellulose in water to obtain mixed solution A, mix potassium hydrogen persulfate and starch, fully mix with mixed solution A, and then dry to obtain drug-loaded pill core 1;

[0052] ②Synthesis of in...

Embodiment 2

[0056] The ingredients and proportions of the preparation and the specific preparation steps were repeated in Example 1, except that the mass ratio of potassium hydrogen persulfate in the drug-carrying pill core 1 was 1.

Embodiment 3

[0058] The ingredients, proportions, and specific preparation steps of the preparation were repeated in Example 1, except that the mass ratio of potassium hydrogen persulfate in the drug-loaded pill core 1 was 1.5.

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Abstract

The invention provides a sustained-release potassium persulfate preparation, which sequentially comprises a drug-carrying pill core, an inner film coating and an outer film coating from inside to outside; the raw material components of the drug-carrying pill core include potassium hydrogen persulfate, Filler, No. 1 plasticizer, sodium carboxymethyl cellulose and water, the raw material components of the inner film coating include ethyl cellulose, No. 2 plasticizer, porogen and organic solvent, the outer The raw material components of the film coating include hydroxypropyl methylcellulose, No. 3 plasticizer, potassium hydrogen persulfate and water. The present invention also provides a preparation method using the above-mentioned sustained-release potassium hydrogen persulfate preparation, comprising the following steps: (1) making a drug-carrying pill core; (2) synthesizing an inner-layer film coating solution; (3) synthesizing an outer-layer film coating solution; (4) coating. The invention can solve the problems of uncontrollable release rate of potassium persulfate, poor treatment effect, complicated operation, easy moisture deterioration and high treatment cost of the existing potassium persulfate preparation during use.

Description

technical field [0001] The invention relates to a sustained-release potassium hydrogen persulfate preparation and a preparation method thereof, belonging to the technical field of water treatment. Background technique [0002] Potassium hydrogen persulfate is often used as a disinfectant, water purifier, bleach and other preparations, and is more and more widely used in various fields because of its super oxidizing properties and its non-toxic oxidation products. At present, in the domestic market, potassium persulfate is usually made into potassium persulfate compound salt preparation to disinfect and purify water bodies. The properties of the potassium hydrogen persulfate compound salt preparation are unstable, and it is easy to be decomposed by water and heat, which affects the effect, so its storage conditions are high; in addition, the potassium hydrogen persulfate contained in the potassium hydrogen persulfate compound salt preparation is expensive. , In the process o...

Claims

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Application Information

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IPC IPC(8): B01J13/02
CPCC02F1/50C02F1/72
Inventor 舒绪刚胡洪超林羽陈铧耀冷淑珍龚圣
Owner ZHONGKAI UNIV OF AGRI & ENG