Electrostatic 3D printing preparation method of polycaprolactone support with rough surface

Abstract

The invention relates to the 3D technology field, and particularly relates to an electrostatic 3D printing preparation method of a polycaprolactone support with a rough surface. The method comprises the following steps that 1, polycaprolactone particles is mixed with glacial acetic acid, the mixture is placed in a closed environment to be stirred until a uniform and transparent solution is obtained, and the configuration concentration is larger than 25 wt%; 2, the transparent solution is placed in a 3D printing platform system, printing of a polymer support is carried out so as to obtain the polycaprolactone three-dimensional support, a receiving substrate board of the 3D printing platform system adopts a metal refrigerating plate, and the temperature of the refrigerating plate is minus 20DEG C- minus 10 DEG C; 3, the polycaprolactone three-dimensional support is frozen by 1-4 hours, then vacuum freeze drying is carried out for 5-12 hours to obtain the polycaprolactone support with the rough surface. Easy controlling is achieved, and the electrostatic 3D printing and preparation of the polycaprolactone three-dimensional support can be conveniently realized; and meanwhile, the preparation of the polycaprolactone three-dimensional support with the rough surface is realized by virtue of a freeze drying process, other chemical substances are not introduced, the forming is convenient and rapid, and the technical scheme of the electrostatic 3D printing field is expanded.

Description

technical field [0001] The invention relates to the field of 3D technology, in particular to an electrostatic 3D printing preparation method of a rough-surfaced polycaprolactone bracket. Background technique [0002] Polycaprolactone is an implantable and degradable biocompatible polymer certified by the US Food and Drug Administration (FDA). Scaffold structures are widely used as matrix materials for tissue engineering bioscaffolds. [0003] At present, among many preparation processes, electrostatic 3D printing technology can realize the controllable printing and construction of three-dimensional polycaprolactone scaffolds from micron to hundreds of microns, which has great advantages in the research of stem cell microenvironment and customized defect tissue regeneration. The prepared polycaprolactone scaffold has a smooth surface, which is not conducive to cell adhesion and proliferation. In order to modify the surface topology, chemical etching is required. This method...

AI Technical Summary

Problems solved by technology

[0003] At present, among many preparation processes, electrostatic 3D printing technology can realize the controllable printing and construction of three-dimensional polycaprolactone scaffolds from micron to hundreds of microns, which has great advantages in the research of stem cell microenvironment and customized defect tissue regeneration. The prepared polycaprolactone scaffold has a smooth surface, which is not conducive to cell adhesion and proliferation

In order to modify the surface topology, chemical etching is required. This method is not only complicated and cumbersome, but also easily introduces toxic and harmful chemical residues, which reduces the safety of polycaprolactone bioscaffolds.

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