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Medicine carrier having effects of slow release and protection on curcumin and preparation method and application of medicine carrier

A drug and carrier technology, which is applied in the field of medicine, can solve the problems of limitation, poor stability, and low water solubility of curcumin, and achieve the effects of good protection, increased dynamic modulus, and improved photostability

Active Publication Date: 2019-03-29
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth noting that although curcumin has a variety of biological activities, its practical application is limited due to some of its own characteristics.
For example: the water solubility of curcumin is extremely low (about 3×10 -8 M) This makes it difficult to incorporate into water soluble products
Another aspect is poor stability

Method used

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  • Medicine carrier having effects of slow release and protection on curcumin and preparation method and application of medicine carrier
  • Medicine carrier having effects of slow release and protection on curcumin and preparation method and application of medicine carrier
  • Medicine carrier having effects of slow release and protection on curcumin and preparation method and application of medicine carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0049] experimental drug

[0050] Lecithin (SL) was purchased from Alfa Aesar Company; Tween 80 (Tween 80, AR), ethyl oleate (EtOL, AR) and curcumin (AR) were all provided by Sinopharm Chemical Reagent Co., Ltd. of China. Water is double distilled water. All medicinal products were used without further processing.

[0051] experimental method

[0052] 1. Drawing of phase diagram

[0053] First, according to the molar ratio of 1 / 1, accurately weigh the surfactant (that is, the molar ratio of Tween80 and SL is 1:1), and mix well; secondly, according to the mass of the surfactant and the oil phase (that is, ethyl oleate) To change the ratio from 10 / 0 to 0 / 10, accurately weigh ethyl oleate in different colorimetric tubes in turn, stir and mix well in a water bath at 60-70°C; finally, drop by drop into the colorimetric tube Add double distilled water (double distilled water), the percentage of water increases at intervals of 2wt%, the interval time is 30min, stir evenly with a ...

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Abstract

The invention provides a medicine carrier having effects of slow release and protection on curcumin and a preparation method and application of the medicine carrier. The medicine carrier is a lyotropic liquid crystal system constructed by a surfactant, an oil phase and water, wherein the surfactant consists of Tween 80 and lecithin, the oil phase is ethyl oleate, and the molar ratio of the Tween 80 to the lecithin in the lyotropic liquid crystal is 1 to 1.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a drug carrier with slow-release and protective effects on curcumin and its preparation method and application. Background technique [0002] Curcumin is a natural polyphenol found in plants. In recent years, studies have found that curcumin has antioxidant, anti-cancer, anti-inflammatory and other activities. And clinical trials have shown that the human body can take 8g of curcumin per day without producing any toxic and side effects, which shows that the natural polyphenolic drug curcumin has high safety. It is worth noting that although curcumin has a variety of biological activities, its practical application is limited due to some of its own characteristics. For example: the water solubility of curcumin is extremely low (about 3×10 -8 M) This makes it difficult to incorporate into water soluble products. Another aspect is poor stability. It is easily decomposed under light cond...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/12A61K47/14A61K47/24A61K47/26A61P1/16A61P3/06A61P29/00A61P35/00A61P39/06
CPCA61K9/1274A61K31/12A61K47/14A61K47/24A61K47/26A61P1/16A61P3/06A61P29/00A61P35/00A61P39/06
Inventor 王仲妮周玉芳张恒戚平岳莹
Owner SHANDONG NORMAL UNIV