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Edible manna lichen formula granules and preparation method thereof

A technology of formula granules and stone fungus, which is applied in the field of formula granules and preparation of stone fungus, to achieve the effects of easy industrialization, improved stability and convenient administration

Inactive Publication Date: 2019-03-29
JIANGXI GROUNDIONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the formula granules and preparation process of Auricularia aculeatus at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The preparation method of the auricularia auricularia formula granule of the present invention comprises the following steps:

[0028] (1) Get the dry Auricularia auricularia medicinal material, pulverize;

[0029] (2) Add 3-5 times the amount of hot water for soaking;

[0030] (3) filter, the filter cake obtained is mixed with the ethanol of 5-10 times of charging capacity;

[0031] (4) ultrasonic extraction 2-3 times;

[0032] (5) filter, and the filtrate is concentrated under reduced pressure to a concentrated solution whose relative density is 1.1-1.2;

[0033] (6) mixing the concentrate with pharmaceutically acceptable adjuvants;

[0034] (7) Freeze-drying, collecting dry cream powder;

[0035] (8) Pulverize the cream powder, cross an 80 mesh sieve, and place it in a mixing tank for mixing;

[0036] (9) Take the Auricularia plaster powder, granulate it, and sieve the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the Auricularia auriculari...

Embodiment 1

[0053] Take 1 kg of dry Auricularia auricularis medicinal material, crush it to 80 mesh, add 4 times the amount of feeding hot water (70 ℃) to soak for 2 hours, filter with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 95% of the amount of feeding 7.5 times. Ethanol was mixed, ultrasonically extracted at an ultrasonic frequency of 90kHz for 3 times, each time for 45 minutes, filtered through a 200-mesh stainless steel mesh, and the filtrate was concentrated under reduced pressure to a concentrated solution with a relative density of 1.15. Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.25:1) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, pulverize through an 80-mesh sieve, and mix in a mixing tank. Take the powder of Auricularia auricularia paste, sieve and granulate the granules, and sieve the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the A1 auri...

Embodiment 2

[0055] Take 1 kg of dried Auricularia auricularis, crush it to 50 mesh, add 4 times the amount of hot water (60 ° C) to soak for 3 hours, filter with 200 mesh stainless steel wire mesh, and mix the obtained filter cake with 95% of the amount of 6 times the amount of feed. Ethanol was mixed, ultrasonically extracted at an ultrasonic frequency of 90 kHz for 3 times, each time for 45 minutes, filtered through a 200-mesh stainless steel mesh, and the filtrate was concentrated under reduced pressure to a concentrated solution with a relative density of 1.12. Add 100g of a mixture of starch, lactose and dextrin (the weight ratio of the three is 1:0.15:1.2) to the concentrated solution for mixing, freeze-dry, collect the dry cream powder, pulverize through an 80-mesh sieve, and mix in a mixing tank. Take the powder of Auricularia auricularia paste, sieve and granulate the granules, and sieve the granules with a 20-mesh sieve and a 50-mesh sieve in turn to obtain the Auricularia auricu...

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Abstract

The invention relates to the technical field of traditional Chinese medicine formula granules, and discloses edible manna lichen formula granules and a preparation method thereof. The method comprisesthe following steps: (1) taking and pulverizing a dried edible manna lichen medicinal material; (2) adding 3 to 5 times of hot water and soaking the pulverized dried edible manna lichen; (3) conducting filtering, and mixing an obtained filter cake with ethanol in an amount 5 to 10 times of feeding; (4) conducting ultrasonic extraction for 2 to 3 times; (5) conducting filtration, and conducting concentration under reduced pressure on a filtrate; (6) mixing a concentrate with pharmaceutically acceptable excipients; (7) conducting freeze-drying, and collecting dry paste powder; (8) pulverizing the dry paste powder, passing the pulverized dry paste powder through an 80 mesh sieve, and conducting mixing in a mixing tank; and (9) taking the edible manna lichen cream powder, conducting granulating, and grading the granules sequentially with a 20 mesh sieve and a 50 mesh sieve. The edible manna lichen formula granules prepared by the method of the present invention have a high active component content and a uniform particle size.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine formula granules, in particular to a stone fungus formula granule and a preparation method thereof. Background technique [0002] Traditional Chinese medicine formula granules are obtained by extracting, separating, concentrating, drying, granulating and packaging the whole ingredients of the medicinal materials through modern processing technology and pharmaceutical technology. They can be directly formulated and packaged without decoction. Granules for ingestion. Traditional Chinese medicine formula granules not only retain the active ingredients, indications and efficacy of traditional Chinese medicine decoction pieces, but also have the advantages that decoction pieces do not have, such as unified standard, stable curative effect, convenient carrying and easy adjustment. Over-the-counter supplements. [0003] Stone ear (Umbilicaria esculenta Miyoshi) is also known as sto...

Claims

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Application Information

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IPC IPC(8): A61K36/09A61K9/16A61P11/00A61P7/00A61P7/04A61P29/00A61P39/02
CPCA61K9/1652A61K36/09A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P7/00A61P7/04A61P11/00A61P29/00A61P39/02
Inventor 廖年生胡贤德眭荣春陈小燕
Owner JIANGXI GROUNDIONG PHARM CO LTD