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Orthopedic implantable scaffold material and its preparation method and application

A stent material and implantable technology, applied in the field of medical devices, can solve problems such as insufficient mechanical strength

Active Publication Date: 2020-03-17
SHENZHEN AOLAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the interconnected porous structure is conducive to cell crawling and nutrient delivery, which can effectively promote bone tissue regeneration, its mechanical strength is obviously insufficient.

Method used

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  • Orthopedic implantable scaffold material and its preparation method and application
  • Orthopedic implantable scaffold material and its preparation method and application
  • Orthopedic implantable scaffold material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The preparation method of the orthopedics implantable bracket material of one embodiment, comprises the steps:

[0037] Step S110: making the initiator adsorb on the base material to obtain a pretreated base material.

[0038] Among them, the matrix material is a porous structure or a fibrous structure. The matrix material of the porous structure or the fiber structure is conducive to the adhesion and crawling growth of cells on the surface of the scaffold material and the transportation of nutrients, and the matrix material of the porous structure or fiber structure is conducive to reducing the weight of the scaffold. The weight of the material. Specifically, the matrix material is one of cellulose, chitosan, sponge and polyurethane foam.

[0039] Wherein, the initiator can be an initiator commonly used in the art. Specifically, the initiator is selected from one of azodiisobutyronitrile (AIBN) and benzoyl peroxide (BPO). These two initiators can be more beneficial ...

Embodiment 1～11

[0065] The preparation process of the orthopedic implantable scaffold material of Examples 1-11 is as follows:

[0066] (1) Soak the base material in the initiator solution for t 1 minutes, then at T 1 Dry at ℃ 2 hours to volatilize the solvent to obtain a pretreated matrix material, wherein the matrix material, the concentration and composition of the initiator solution, and the soaking time t 1 , drying temperature T 1 and drying time t 2 As shown in Table 1.

[0067] (2) Use the precursor gas source to carry out vacuum coating treatment on the pretreated base material obtained in step (1), to form a thickness D on the base material 1 Micron film layer. Among them, the process parameters of the vacuum coating process and the thickness of the film layer D 1 As shown in Table 2, the composition of the precursor gas source of each embodiment is shown in Table 3.

[0068] (3) Place the matrix material with the precursor formed in step (2) in a plasma generator to perform...

Embodiment 12～22

[0079] The preparation process of the orthopedic implantable scaffold material in Examples 12-22 is as follows:

[0080] (1) Soak the base material in the initiator solution for t 3 minutes, then at T 2 Dry at ℃ 4 hours to volatilize the solvent to obtain a pretreated matrix material, wherein the matrix material, the concentration and composition of the initiator solution, and the soaking time t 3 , drying temperature T 2 and drying time t 4 As shown in Table 4.

[0081] (2) Use the precursor gas source to carry out vacuum coating treatment on the pretreated base material obtained in step (1), to form a thickness D on the base material 2Micron film layer. Among them, the process parameters of the vacuum coating process and the thickness of the film layer D 2 As shown in Table 5, the composition of the precursor gas source of each embodiment is shown in Table 6.

[0082] (3) Place the matrix material formed with the precursor in step (2) in a plasma generator to perform...

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Abstract

The invention relates to an implantable support material for the orthopedics department and a preparation method and application of the implantable support material. The preparation method of the implantable support material for the orthopedics department includes the following steps that a precursor gas source is used for carrying out vacuum coating treatment on a base material, and then a thin film layer is formed on the base material, wherein the precursor gas source is selected from at least one of styrene, acrylic and parylene monomers, and the base material is of a porous structure or afiber structure; and the thin film layer is subjected to surface modification treatment, and the implantable support material for the orthopedics department is obtained. The implantable support material for the orthopedics department prepared with the preparation method has good biocompatibility, good bone inductivity and high compression strength.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an orthopedic implantable bracket material and its preparation method and application. Background technique [0002] The materials currently used for bone repair are mainly divided into the following categories: 1. Natural bone materials; 2. Medical metal materials; 3. Medical bioceramics; 4. Medical polymers; 5. Medical composite materials. At present, autologous bone is the most commonly used in orthopedic transplantation, but the source of autologous bone is limited, and at the same time, it will cause bone defects. The mechanics of metal bone is an order of magnitude higher than that of human bone, but it is easy to cause stress shielding, which leads to bone remodeling degradation at the graft site, and eventually loosening. The latest biocompatible degradable scaffold can react with the body, degrade the scaffold while regenerating bone, and replace the scaffold with its own...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C16/02C23C16/455C23C16/56A61L27/56A61L27/28
CPCA61L27/28A61L27/56A61L2420/02A61L2430/02C23C16/0272C23C16/455C23C16/56
Inventor 苏建华云洋
Owner SHENZHEN AOLAN TECH CO LTD